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Titolo:
AGONIST-INDUCED MUSCARINIC CHOLINERGIC RECEPTOR INTERNALIZATION, RECYCLING AND DEGRADATION IN CULTURED NEURONAL CELLS - CELLULAR MECHANISMSAND ROLE IN DESENSITIZATION
Autore:
MALOTEAUX JM; HERMANS E;
Indirizzi:
UNIV CATHOLIQUE LOUVAIN,NEUROCHIM LAB 1352,AVE HIPPOCRATE 10 B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,DEPT NEUROPSYCHIAT B-1200 BRUSSELS BELGIUM
Titolo Testata:
Biochemical pharmacology
fascicolo: 1, volume: 47, anno: 1994,
pagine: 77 - 88
SICI:
0006-2952(1994)47:1<77:AMCRIR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; CYCLIC-GMP FORMATION; PROTEIN KINASE-C; EPIDERMAL GROWTH-FACTOR; MOUSE PERITONEAL-MACROPHAGES; CEREBELLAR GRANULE CELLS; LOW-DENSITY LIPOPROTEIN; INDUCED DOWN-REGULATION; SHORT-TERM REGULATION; 3RD CYTOPLASMIC LOOP;
Keywords:
DESENSITIZATION; INTERNALIZATION; DOWN-REGULATION; MUSCARINIC RECEPTORS; [H-3] METHYLSCOPOLAMINE; CELL CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
125
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Maloteaux e E. Hermans, "AGONIST-INDUCED MUSCARINIC CHOLINERGIC RECEPTOR INTERNALIZATION, RECYCLING AND DEGRADATION IN CULTURED NEURONAL CELLS - CELLULAR MECHANISMSAND ROLE IN DESENSITIZATION", Biochemical pharmacology, 47(1), 1994, pp. 77-88

Abstract

Short-term incubation of intact neuronal cells with muscarinic cholinergic agonists resulted in a rapid decrease of the specific binding of[H-3]methylscopolamine to cell surface receptors indicative of receptor internalization. The agonists induced the internalization of both the muscarinic receptor subtypes coupled to adenylyl cyclase and those coupled to phosphoinositide turnover. Receptor internalization, which was inhibited at 0-4 degrees and by depletion of intracellular K+ is thought to occur through coated pits formation and was rapidly reversible. Receptor recycling did not imply protein synthesis. Down-regulation of muscarinic receptors occurred slowly in the presence of agonists,needed intact cytoskeleton (demonstrated by the inhibitory effect of colchicine) and involved lysosomal activity. Both receptor internalization and down-regulation were prevented by muscarinic receptor antagonists. Receptor internalization and down-regulation are agonist-inducedcellular mechanisms that with receptor phosphorylation and uncoupling, may induce desensitization. These processes may contribute to complex intracellular regulatory processes and may be involved in some of the long-term effects of neurotransmitters (mainly neuropeptides and growth hormones) or drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:29:08