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Titolo:
FROM RECEPTOR INTERNALIZATION TO NUCLEAR TRANSLOCATION - NEW TARGETS FOR LONG-TERM PHARMACOLOGY
Autore:
LADURON PM;
Indirizzi:
UCL,NEUROCHIM LAB,10 AV HIPPOCRATE B-1200 BRUSSELS BELGIUM UNIV LOUVAIN,SCH PHARM B-1200 BRUSSELS BELGIUM
Titolo Testata:
Biochemical pharmacology
fascicolo: 1, volume: 47, anno: 1994,
pagine: 3 - 13
SICI:
0006-2952(1994)47:1<3:FRITNT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; BETA-ADRENERGIC-RECEPTOR; NERVE GROWTH-FACTOR; LIGAND-INDUCED INTERNALIZATION; SQUAMOUS-CELL CARCINOMA; GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; CARBOXYL TERMINUS; BETA-2-ADRENERGIC RECEPTOR; INDUCED DESENSITIZATION;
Keywords:
RECEPTOR INTERNALIZATION; DESENSITIZATION; AXONAL TRANSPORT; MICROTUBULE; 3RD MESSENGER; NUCLEAR TRANSLOCATION; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Laduron, "FROM RECEPTOR INTERNALIZATION TO NUCLEAR TRANSLOCATION - NEW TARGETS FOR LONG-TERM PHARMACOLOGY", Biochemical pharmacology, 47(1), 1994, pp. 3-13

Abstract

Receptors involved in intercellular communication at the cell surfaceshare the capacity to desensitize through molecular and cellular mechanisms. Cellular desensitization is a rapid and dynamic process whereby membrane receptors internalize in response to an excess of agonists. The internalized receptors may recycle rapidly or undergo down-regulation when following a degradative pathway. However, receptor internalization does not necessarily mean degradation; it also represents the initial step of a retrograde signalling system whereby an ''interiorized'' message, the ligand-receptor complex, can be transported in contrast to second messengers, along axons or in the cytoplasm leading to longterm effects in the nucleus. Such ''third messengers'' have to undergo nuclear translocation to serve as transcriptional regulators in thecontrol of gene expression. The ''third messengers'' are thus cytoplasmic proteins, including the receptor itself, which may be associated with internalized vesicles and released by mechanisms which have not yet been elucidated. They represent already good targets for the development of new drugs, and multitargeting and synergistic approaches are likely to increase their usefulness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 13:35:02