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Titolo:
THE CONTRIBUTION OF PERIPHERAL BRADYKININ B-2 RECEPTORS TO CARRAGEENAN-EVOKED EDEMA AND SPINAL C-FOS EXPRESSION IN RATS
Autore:
BURITOVA J; CHAPMAN V; HONORE P; BESSON JM;
Indirizzi:
INSERM,U161,UNITE RECH PHYSIOPHARMACOL SYST NERVEUX,2 RUE ALESIA F-75014 PARIS FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 320, anno: 1997,
pagine: 73 - 80
SICI:
0014-2999(1997)320:1<73:TCOPBB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPIRIN-LIKE DRUGS; TRANSGANGLIONIC TRANSPORT; GENE-EXPRESSION; FORMALIN TEST; HYPERALGESIA; PAIN; INFLAMMATION; ANTAGONIST; HOE-140; PROSTAGLANDINS;
Keywords:
BRADYKININ; CARRAGEENAN INFLAMMATION; C-FOS; NOCICEPTION; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J. Buritova et al., "THE CONTRIBUTION OF PERIPHERAL BRADYKININ B-2 RECEPTORS TO CARRAGEENAN-EVOKED EDEMA AND SPINAL C-FOS EXPRESSION IN RATS", European journal of pharmacology, 320(1), 1997, pp. 73-80

Abstract

Intraplantar co-injection of HOE140 (D-Arg-[Hyp(3),Thi(5),D-Tic(7),Oic(8)]bradykinin), a selective bradykinin B-2 receptor antagonist (0.1,1 and 10 mu g), with carrageenan dose-dependently (r = 0.66, P < 0.01) reduced the carrageenan-evoked total number of c-Fos protein-like immunoreactive (c-Fos-LI) neurones (23 +/- 5%, 35 +/- 6% and 50 +/- 5% reduction; P < 0.01, P < 0.001 and P < 0.001, respectively). These reducing effects were dose-dependent for the number of c-Fos-LI neurones in both superficial (r = 0.70, P < 0.01) and deep (r = 0.53, P < 0.05) laminae. Intraplantar co-injection of HOE140 (0.1, 1 and 10 mu g) withcarrageenan significantly reduced the carrageenan-evoked paw (25 +/- 7% 41 +/- 6% and 41 +/- 3% reduction; P < 0.001 for all) and ankle (46+/- 6%, 61 +/- 5% and 61 +/- 5% reduction; P < 0.001 for all) oedema. Our results provide further evidence for the involvement of peripheral bradykinin B, receptors in carrageenan-induced inflammatory nociceptive transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:11:06