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Titolo:
INVERSE PATTERNS OF MYELINATION AND GAP-43 EXPRESSION IN THE ADULT CNS - NEURITE GROWTH-INHIBITORS AS REGULATORS OF NEURONAL PLASTICITY
Autore:
KAPFHAMMER JP; SCHWAB ME;
Indirizzi:
UNIV ZURICH,BRAIN RES INST,AUGUST FOREL STR 1 CH-8029 ZURICH SWITZERLAND
Titolo Testata:
Journal of comparative neurology
fascicolo: 2, volume: 340, anno: 1994,
pagine: 194 - 206
SICI:
0021-9967(1994)340:2<194:IPOMAG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE INJURY; RAT SPINAL-CORD; SEGMENTED POSTSYNAPTIC DENSITIES; CORTICOSPINAL TRACT AXONS; MOUSE OLFACTORY-BULB; PROTEIN GAP-43; IMMUNOHISTOCHEMICAL LOCALIZATION; IMMUNOCYTOCHEMICAL DISTRIBUTION; REACTIVE SYNAPTOGENESIS; SYNAPTIC REORGANIZATION;
Keywords:
SPROUTING; SYNAPTIC PLASTICITY; OLIGODENDROCYTES; IMMUNOHISTOCHEMISTRY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Kapfhammer e M.E. Schwab, "INVERSE PATTERNS OF MYELINATION AND GAP-43 EXPRESSION IN THE ADULT CNS - NEURITE GROWTH-INHIBITORS AS REGULATORS OF NEURONAL PLASTICITY", Journal of comparative neurology, 340(2), 1994, pp. 194-206

Abstract

In the central nervous system (CNS) myelin is present not only in white matter, but also in varying amounts in many gray matter areas. In addition to the function of electrical insulation of axons, myelin and oligodendrocytes contain molecules that are powerful inhibitors of neurite growth. Nevertheless plastic changes involving sprouting of nerveterminals occur in several brain regions of adult animals after partial lesions. In this study we have tried to correlate the plastic potential of CNS regions with the degree of their myelination. The expression of the growth-associated protein GAP-43 was used as an indicator ofthe potential for plastic changes, and a histological myelin stain was used to assess myelination. We have found that myelination and GAP-43 expression have strikingly inverse expression patterns in the majority of CNS gray matter areas. Densely myelinated regions, that is, mostbrainstem nuclei, the tegmentum, and the inferior colliculus, are lowin GAP-43. In contrast, unmyelinated or lightly myelinated areas, such as the substantia gelatinosa of the spinal cord, the nucleus of the solitary tract, or the septum, express high levels of GAP-43. Areas known to show lesion-induced sprouting are typically high in GAP-43 and only lightly myelinated. During postnatal development the myelination pattern precedes the GAP-43 pattern, a sequence that is consistent with a role of myelin and the associated neurite growth inhibitors in modifying GAP-43 expression. Our results support the hypothesis that myelin-associated neurite growth inhibitors are involved in regulating thestability of neural connections. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:08:38