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Titolo:
EFFICACY AND SAFETY OF INDOMETHACIN THERAPY FAR POLYHYDRAMNIOS
Autore:
CARMONA F; MARTINEZROMAN S; MORTERA C; PUERTO B; CARARACH V; IGLESIAS X;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,FAC MED,DEPT OBSTET & GYNECOL,C VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,FAC MED,DEPT PEDIAT E-08036 BARCELONASPAIN
Titolo Testata:
European journal of obstetrics, gynecology, and reproductive biology
fascicolo: 3, volume: 52, anno: 1993,
pagine: 175 - 180
SICI:
0301-2115(1993)52:3<175:EASOIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL DUCTUS-ARTERIOSUS; SYMPTOMATIC POLYHYDRAMNIOS; PREMATURE LABOR; URINE OUTPUT; PREGNANCY; OLIGOHYDRAMNIOS; ASSOCIATION; HYDRAMNIOS; EXPOSURE; AGENTS;
Keywords:
INDOMETHACIN THERAPY; POLYHYDRAMNIOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F. Carmona et al., "EFFICACY AND SAFETY OF INDOMETHACIN THERAPY FAR POLYHYDRAMNIOS", European journal of obstetrics, gynecology, and reproductive biology, 52(3), 1993, pp. 175-180

Abstract

The maternal and perinatal outcome of seven gravidas receiving 2.2-2.5 mg/kg per day of indomethacin for polyhydramnios are reported. Such therapy was started between 26 and 33 weeks of gestational age (mean, 30.4 weeks) and lasted for 20.1 days (range, 2-37 days). Median of amniotic fluid index ranged from 47 at the start of therapy (range, 32-53) to 15 (range, 2-50) when indomethacin was ended. Interval between the end of the therapy and the delivery ranged from 0 to 45 days (mean, 15 days). On average, pregnancies were prolonged by 5.1 weeks (range, 2-8 weeks). The newborn weight was 2678 g on average (range, 620-3700 g). Oligohydramnios was seen in two instances; one patient developed constriction of the fetal ductus arteriosus, which returned to normality after indomethacin supression; one newborn in which other casuses ofneonatal bleeding could be excluded, developed a diseminated intravascular coagulation and died 15 h after birth. Finally, one mother presented an acute renal failure immediately after indomethacin administration; this patient completely recovered after indomethacin withdrawal. Thus, the benefit of pregnancy prolongation should be balanced againstthe increased risks for the newborn, mainly fetal ductus arteriosus constriction and possible bleeding disorders. A causal relationship of indomethacin administration to the latter complication warrants further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:39:58