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Titolo:
DIFFERENTIAL HUMAN RENAL TUBULAR RESPONSES TO DOPAMINE TYPE-1 RECEPTOR STIMULATION ARE DETERMINED BY BLOOD-PRESSURE STATUS
Autore:
OCONNELL DP; RAGSDALE NV; BOYD DG; FELDER RA; CAREY RM;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT MED,BOX 395 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT MED CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT PATHOL CHARLOTTESVILLE VA 22908 NATL UNIV IRELAND UNIV COLL CORK,DEPT THERAPEUT & PHARMACOL CORK IRELAND
Titolo Testata:
Hypertension
fascicolo: 1, volume: 29, anno: 1997,
parte:, 1
pagine: 115 - 122
SICI:
0194-911X(1997)29:1<115:DHRTRT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; PROXIMAL CONVOLUTED TUBULE; ADENYLATE-CYCLASE; K+-ATPASE; LITHIUM; MICROPUNCTURE; KIDNEY; DEFECT;
Keywords:
RECEPTORS, DOPAMINE; BLOOD PRESSURE; KIDNEY TUBULES, PROXIMAL; DOPAMINE AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Oconnell et al., "DIFFERENTIAL HUMAN RENAL TUBULAR RESPONSES TO DOPAMINE TYPE-1 RECEPTOR STIMULATION ARE DETERMINED BY BLOOD-PRESSURE STATUS", Hypertension, 29(1), 1997, pp. 115-122

Abstract

We performed the present studies to determine whether a proximal renal tubular dopamine D-1-like receptor defect exists in human essential hypertension. Twenty-four subjects were studied (13 normotensive and 11 hypertensive) in a randomized, double-blind, vehicle-controlled study using fenoldopam, a selective D-1-like receptor agonist. Subjects were studied in sodium metabolic balance at 300 mEq/d, after which the salt sensitivity of their blood pressure was determined. Fenoldopam at peak doses of 0.1 to 0.2 mu g/kg per minute decreased mean arterial pressure in hypertensive subjects but did not change mean pressure in normotensive subjects. Fenoldopam increased renal plasma flow to a greater extent in hypertensive than normotensive subjects. Fenoldopam increased both urinary and fractional sodium excretions in the hypertensiveand normotensive groups. In normotensive but not hypertensive subjects, fenoldopam increased the fractional excretion of lithium and distalsodium delivery. In contrast, both distal fractional sodium reabsorption and sodium-potassium exchange fell significantly in hypertensive subjects. We conclude that human essential hypertension is associated with a reduction in the proximal tubular response to D-1-like receptor stimulation compared with normotensive subjects. Hypertensive subjectsappear to have a compensatory upregulation of renal vascular and distal tubular D-1-like receptor function that offsets the proximal tubular defect, resulting in an enhanced natriuretic response to D-1-like receptor stimulation.

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Documento generato il 04/04/20 alle ore 15:03:32