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Titolo:
VASCULAR ALDOSTERONE IN GENETICALLY HYPERTENSIVE RATS
Autore:
TAKEDA Y; MIYAMORI I; INABA S; FURUKAWA K; HATAKEYAMA H; YONEDA T; MABUCHI H; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT HLTH SCI KANAZAWA ISHIKAWA 920 JAPAN KKR HOKURIKU HOSP KANAZAWA ISHIKAWA JAPAN
Titolo Testata:
Hypertension
fascicolo: 1, volume: 29, anno: 1997,
parte:, 1
pagine: 45 - 48
SICI:
0194-911X(1997)29:1<45:VAIGHR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENIN-ANGIOTENSIN SYSTEM; SMOOTH-MUSCLE CELLS; NA-K-ATPASE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MESENTERIC-ARTERIES; GENE-EXPRESSION; BINDING; RECEPTORS;
Keywords:
ALDOSTERONE; RATS, INBRED SHR; RECEPTORS, MINERALOCORTICOID; NA+,K+-EXCHANGING ATPASE; RNA, MESSENGER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "VASCULAR ALDOSTERONE IN GENETICALLY HYPERTENSIVE RATS", Hypertension, 29(1), 1997, pp. 45-48

Abstract

We have reported that aldosterone is synthesized and cytochrome P450aldo mRNA exists in the vasculature. To clarify the pathophysiological role of vascular aldosterone in hypertension, we compared aldosterone production in the mesenteric arteries of stroke-prone spontaneously hypertensive rats (SHRSP) with that in Wistar-Kyoto rats (WKY). The expressions of mRNA of cytochrome P450aldo, mineralocorticoid receptor, and alpha(1), Na,K-ATPase in the mesenteric arteries were compared between the two groups. Aldosterone concentration in the perfusate of the vasculature was measured by radioimmunoassay after purification with high-performance liquid chromatography. Cytochrome P450aldo and mineralocorticoid receptor mRNA levels were quantified by Southern blot analysis of the products of reverse-transcribed polymerase chain reaction. Levels of alpha(1) Na,K-ATPase mRNA were measured by Northern blot analysis. Vascular aldosterone and cytochrome P450aldo mRNA levels of 2-week-old SHRSP were significantly increased compared with those of age-matched WKY. However, vascular aldosterone in 4- and 9-week-old SHRSP did not differ from that in age-matched WKY. Expression levels of mineralocorticoid receptor mRNA in the vasculature of 4- and 9-week-old SHRSP were Significantly increased compared with those in age-matched WKY. Concentrations of vascular alpha(1) Na,K-ATPase mRNA of 2-, 4-, and 9-week-old SHRSP also were significantly higher than those in age-matched WKY. These results suggest that vascular aldosterone contributes to the pathophysiology of hypertension in SHRSP in the early stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:18:01