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Titolo:
CURATIVE EFFECTS OF THE ATYPICAL ANTIDEPRESSANT MIANSERIN IN THE CHRONIC MILD STRESS-INDUCED ANHEDONIA MODEL OF DEPRESSION
Autore:
MOREAU JL; BOURSON A; JENCK F; MARTIN JR; MORTAS P;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,PRECLIN RES,DIV PHARMA CH-4002 BASEL SWITZERLAND
Titolo Testata:
Journal of psychiatry & neuroscience
fascicolo: 1, volume: 19, anno: 1994,
pagine: 51 - 56
SICI:
1180-4882(1994)19:1<51:CEOTAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACRANIAL SELF-STIMULATION; BRAIN REWARD CIRCUITRY; ANIMAL-MODEL; MESOLIMBIC DOPAMINE; DESMETHYLIMIPRAMINE; HYPOTHESIS; PREFERENCE; BEHAVIOR; REVERSAL;
Keywords:
ANHEDONIA; DEPRESSION; STRESS; MIANSERIN; SELF-STIMULATION; REWARD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Moreau et al., "CURATIVE EFFECTS OF THE ATYPICAL ANTIDEPRESSANT MIANSERIN IN THE CHRONIC MILD STRESS-INDUCED ANHEDONIA MODEL OF DEPRESSION", Journal of psychiatry & neuroscience, 19(1), 1994, pp. 51-56

Abstract

This study was designed to validate a novel animal model of depression by testing the curative effects of the atypical antidepressant mianserin. In this paradigm, the hedonic state of rats was assessed using an intracranial self-stimulation (ICSS) procedure. The ICSS threshold was determined before, during and after a 38-day period of exposure to a variety of intermittent, unpredictable, mild stressors. After 11 days of this regimen, the ICSS threshold was significantly higher in the stressed rats, suggesting a gradual decrease of sensitivity to reward. This ''anhedonia'' lasted throughout the stress regimen and progressively diminished over a 20-day period after stress was terminated. Whenstressed animals exhibiting anhedonia were treated with mianserin, the stress-induced increase in the ICSS threshold was gradually reversedover ten days of treatment. These results provide further support forthe value of this anhedonia paradigm in modelling an important aspectof human depressive disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:21