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Titolo:
ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS AS POTENTIAL COGNITIVE ENHANCING AGENTS
Autore:
DOMENEY AM;
Indirizzi:
BATTELLE RES INST,DIV HLTH,7 ROUTE DRIZE CH-1227 GENEVA SWITZERLAND UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND
Titolo Testata:
Journal of psychiatry & neuroscience
fascicolo: 1, volume: 19, anno: 1994,
pagine: 46 - 50
SICI:
1180-4882(1994)19:1<46:AEAPCE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
II RECEPTOR ANTAGONISTS; RAT-BRAIN; ALZHEIMERS-DISEASE; TEMPORAL CORTEX; ACE INHIBITORS; CAPTOPRIL; SUBTYPES; MEMORY; ENALAPRIL; ATENOLOL;
Keywords:
ANGIOTENSIN CONVERTING ENZYME INHIBITORS; NONPEPTIDE ANGIOTENSIN II RECEPTOR LIGANDS; COGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Domeney, "ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS AS POTENTIAL COGNITIVE ENHANCING AGENTS", Journal of psychiatry & neuroscience, 19(1), 1994, pp. 46-50

Abstract

Anecdotal reports of a mood-elevating effect in patients and improvements in the performance of memory tests in the clinic has led to investigations into the nootropic actions of angiotensin converting enzyme (ACE) inhibitors. A cognitive enhancing action for the ACE inhibitors has been demonstrated in a number of animal models of memory function. Neurochemical studies in animals have shown that angiotensin II acting via an angiotensin II receptor can inhibit the release of (3)HAch from entorhinal cortex slices. Thus the ability of ACE inhibitors to facilitate cognitive processes may be related to reduced availability of angiotensin II. Lack of specificity of ACE inhibitors may be a limiting factor in the development of such compounds as cognitive enhancers. However, the recent development of selective antagonists for subtypes of the angiotensin II receptor may represent a novel approach for the treatment of cognitive disorders with an underlying cholinergic disturbance.

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Documento generato il 17/01/20 alle ore 20:13:52