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Titolo:
A CONTROLLED CLINICAL-TRIAL WITH A SPECIFICALLY CONFIGURED RNA DRUG, POLY(I)CENTER-DOT-POLY(C12U), IN CHRONIC FATIGUE SYNDROME
Autore:
STRAYER DR; CARTER WA; BRODSKY I; CHENEY P; PETERSON D; SALVATO P; THOMPSON C; LOVELESS M; SHAPIRO DE; ELSASSER W; GILLESPIE DH;
Indirizzi:
HAHNEMANN UNIV,SCH MED,MS 412,BROAD & VINE PHILADELPHIA PA 19102 HEM PHARMACEUT CORP PHILADELPHIA PA 00000 CFS CLIN CHARLOTTE NC 00000 CFS CLIN INCLINE VILLAGE NV 00000 HOUSTON IMMUNOL INST HOUSTON TX 00000 UNIV OREGON PORTLAND OR 00000
Titolo Testata:
Clinical infectious diseases
, volume: 18, anno: 1994, supplemento:, 1
pagine: 190000088 - 190000095
SICI:
1058-4838(1994)18:<190000088:ACCWAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; AIDS-RELATED COMPLEX; DOUBLE-STRANDED-RNA; INFECTION; DEFINITION; ILLNESS; QUALITY; DISEASE; CELLS; LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Strayer et al., "A CONTROLLED CLINICAL-TRIAL WITH A SPECIFICALLY CONFIGURED RNA DRUG, POLY(I)CENTER-DOT-POLY(C12U), IN CHRONIC FATIGUE SYNDROME", Clinical infectious diseases, 18, 1994, pp. 190000088-190000095

Abstract

Chronic fatigue syndrome (CFS) is a physically debilitating illness associated with immunologic abnormalities, viral reactivation, and impairment of cognition. In a randomized, multicenter, placebo-controlled,double-blind study of 92 patients meeting the CFS case definition of the Centers for Disease Control and Prevention, the response of several laboratory and clinical variables to an antiviral and immunomodulatory drug, poly(I) poly(C12U), was determined. Measures of clinical response included Karnofsky performance score, a cognition scale derived from a self-administered instrument assessing symptomatology (SCL-90-R), an activities of daily living scale, and exercise treadmill performance. After 24 weeks, patients receiving poly(I) poly(C12U) had higher scores for both global performance and perceived cognition than did patients receiving placebo. In particular, patients given poly(I) poly(C12U) had increased Karnofsky performance scores (P < .03), exhibited agreater ability to do work during exercise treadmill testing (P = .01), displayed an enhanced capacity to perform the activities of daily living (P < .04), had a reduced cognitive deficit (P = .05), and required less use of other medications (P < .05).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:20:54