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Titolo:
MANTLE ZONE LYMPHOMA - AN IMMUNOHISTOLOGIC STUDY OF SKIN-LESIONS
Autore:
BERTERO M; NOVELLI M; FIERRO MT; BERNENGO MG;
Indirizzi:
CLIN DERMATOL,VIA CHERASCO 23 I-10126 TURIN ITALY UNIV TURIN,DERMATOL CLIN 1 I-10126 TURIN ITALY
Titolo Testata:
Journal of the American Academy of Dermatology
fascicolo: 1, volume: 30, anno: 1994,
pagine: 23 - 30
SICI:
0190-9622(1994)30:1<23:MZL-AI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE LYMPHOCYTIC LYMPHOMA; LOW-GRADE LYMPHOMAS; SMALL CLEAVED CELL; MALIGNANT-LYMPHOMA; HYPERPLASIA; ANTIGENS; DIFFUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Bertero et al., "MANTLE ZONE LYMPHOMA - AN IMMUNOHISTOLOGIC STUDY OF SKIN-LESIONS", Journal of the American Academy of Dermatology, 30(1), 1994, pp. 23-30

Abstract

Background: Mantle zone lymphoma (MZL) is a B-cell proliferation regarded as the follicular variant of intermediate lymphocytic lymphoma (ILL). Neoplastic small lymphoid cells proliferate as wide mantles around atrophic centers of benign appearance. Objective: The clinical, histologic, and immunohistochemical features of four cases of MZL, heralded by cutaneous lesions, are described and correlated with the lymph node pattern. Results: Ah specimens showed extensive nodules in the reticular dermis invading the subcutaneous tissue. They were mainly composed of a proliferation of small lymphocytes with slightly irregular nuclear contours and clumped chromatin, forming wide mantles around smallatrophic germinal centers. Serial biopsy specimens in case 1 revealedevolution of the skin lesions from pseudolymphoma into MZL. Their immunohistochemistry was similar to that of lymph nodes and showed that the neoplastic cells were CD5(+), CD20(+), CD22(+), CD25(+), CD74(+), Leu-8(+), HLA-DR(+), IgM(+), IgD(+) with restriction for the X light chain, CD10(-), and CD71(-), whereas the germinal center cells were polyclonal. In three cases many CD38(+), PCA-1(+) plasma cells were present both in the grenz zone and in bordering neoplastic nodules. The clinical course was chronic. The only death occurred from unrelated causes; one patient is still alive 17 years after onset. Conclusion: Skin lesions may be the only manifestation of MZL for an extended period. Thedifferentiation between pseudolymphoma and other lymphoma subtypes isbased not only on the histologic and cytologic features but also on the architecture, followed by immunohistochemical confirmation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:42:58