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Titolo:
ACUTE BIOLOGICAL RESPONSE TO LASER BALLOON ANGIOPLASTY IN THE ATHEROSCLEROTIC RABBIT
Autore:
ALEXOPOULOS D; SANBORN TA; MARMUR JD; BADIMON JJ; BADIMON L; DISCHE R; FUSTER V;
Indirizzi:
CORNELL UNIV,MED CTR,NEW YORK HOSP,CARDIAC CATHETERIZAT LAB,ROOM ST-445,525 E 68TH ST NEW YORK NY 10021 MT SINAI MED CTR,DEPT MED NEW YORK NY 10021 MT SINAI MED CTR,DEPT PATHOL,DIV CARDIOL NEW YORK NY 10021 NEW YORK CARDIAC CTR ENGLEWOOD CLIFFS NJ 00000
Titolo Testata:
Lasers in surgery and medicine
fascicolo: 1, volume: 14, anno: 1994,
pagine: 7 - 12
SICI:
0196-8092(1994)14:1<7:ABRTLB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
WALL; THROMBOGENICITY; SEPARATIONS; PLAQUE;
Keywords:
LASER BALLOON ANGIOPLASTY; LASER ENERGY; RABBITS; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D. Alexopoulos et al., "ACUTE BIOLOGICAL RESPONSE TO LASER BALLOON ANGIOPLASTY IN THE ATHEROSCLEROTIC RABBIT", Lasers in surgery and medicine, 14(1), 1994, pp. 7-12

Abstract

Laser balloon angioplasty with Nd:YAG; energy has been proposed as a method to seal intimal dissection and prevent elastic recoil after balloon angioplasty. To better define the vessel response to laser balloon angioplasty, its effects on luminal diameter, Indium-111 labelled platelet deposition, and histology were studied in 10 atherosclerotic rabbits. Balloon angioplasty was performed in both iliac arteries and was followed by laser balloon angioplasty in only one iliac artery. The nonlased artery served as a control. Single (15-35 W for 20 sec) or repetitive laser pulses (12-25 W for 20 sec x 3) were used. Platelet deposition was quantified 2 hr after the intervention. Lumen diameter (mm) increased following balloon angioplasty from 0.99 +/- 0.47 ( mean +/- SD) to 1.92 +/- 0.43 and 0.89 +/- 0.46 to 1.99 +/- 0.57 in the balloon and laser-treated arteries, respectively (P < 0.001 for both groupsfor comparisons to baseline, P = NS for between groups comparison). Laser balloon angioplasty resulted in a further increase in luminal diameter to 2.42 +/- 0.53 (P < 0.02) when compared to the post balloon angioplasty diameter. Platelet deposition (10(6)/cm vessel) was higher following laser balloon angioplasty (26.9, 10.2-189; median range) thanafter balloon angioplasty (10.6, 3.4-30), P < 0.001. Histologic evidence of laser ''sealing'' was present in only one artery. Thus althoughlaser balloon angioplasty results in an improved lumen diameter, it is accompanied by increased platelet deposition. In the atheroscleroticrabbit model, abolition of vascular recoil rather than ''sealing'' seems to be the most important advantage of laser balloon angioplasty over conventional balloon angioplasty. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:03:01