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Titolo:
PREVENTION OF RETHROMBOSIS AFTER CORONARY THROMBOLYSIS IN A CHRONIC CANINE MODEL .2. ADJUNCTIVE THERAPY WITH R-HIRUDIN
Autore:
ROTE WE; MU DX; BATES ER; NEDELMAN MA; LUCCHESI BR;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,M6322 MED SCI 1 ANN ARBOR MI 48108 UNIV MICHIGAN,SCH MED,DEPT PHARMACOL ANN ARBOR MI 48108 UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED CARDIOL ANN ARBOR MI 00000 CENTOCOR INC MALVERN PA 00000
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 2, volume: 23, anno: 1994,
pagine: 203 - 211
SICI:
0160-2446(1994)23:2<203:PORACT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ANTITHROMBOTIC AGENTS; PLASMINOGEN-ACTIVATOR; PLATELET-AGGREGATION; ARTERIAL THROMBOSIS; ANTIPLATELET AGENTS; UNSTABLE ANGINA; IIIA RECEPTOR; HEPARIN; REPERFUSION;
Keywords:
INFARCT; PLATELETS; RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR; THROMBIN; THROMBOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
W.E. Rote et al., "PREVENTION OF RETHROMBOSIS AFTER CORONARY THROMBOLYSIS IN A CHRONIC CANINE MODEL .2. ADJUNCTIVE THERAPY WITH R-HIRUDIN", Journal of cardiovascular pharmacology, 23(2), 1994, pp. 203-211

Abstract

We examined the effectiveness of the direct-acting thrombin inhibitor, recombinant hirudin (r-hirudin), for prevention of coronary rethrombosis after thrombolysis with recombinant tissue plasminogen activator (rt-PA) in a canine model of coronary artery thrombosis. The reocclusion rate of 15-30% associated with thrombolytic therapy emphasizes the need for adjuctive therapy to prevent rethrombosis. We studied r-hirudin for its potential to prevent reocclusion in a model of coronary artery thrombosis/thrombolysis. The circumflex coronary arteries of anesthetized dogs were instrumented with a flow probe, an intraluminal electrode, and a ligature stenosis. The dogs were reanesthetized on the ninth postoperative day, and intimal injury was induced with an anodal current. After occlusive thrombus formation, tissue plasminogen activator (rt-PA) was administered. The animals were allocated to receive either placebo, r-hirudin [5 mg/kg intravenously (i.v.) bolus, 2 mg/kg/h i.v., for 3.5 hi or r-hirudin (5 mg/kg i.v., bolus, 1 mg/kg/h i.v., for 12 h). Neither aspirin nor heparin was used. Ex vivo platelet function and coronary artery blood flow velocity were recorded on each of 5 consecutive days. Infarct size and residual thrombus weight were determined at the end of the protocol. r-Hirudin infusion (3.5 and 12 h) provided little benefit over rt-PA alone. Ex vivo platelet aggregation was not affected by r-hirudin. Little improvement in the incidence of reocclusion and mortality in a model of coronary artery thrombosis/thrombolysis resulted from adjunctive treatment with r-hirudin.

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Documento generato il 04/12/20 alle ore 03:23:34