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Titolo:
CYCLIC ADP-RIBOSE, THE ADP-RIBOSYL CYCLASE PATHWAY AND CALCIUM SIGNALING
Autore:
GALIONE A;
Indirizzi:
UNIV OXFORD,DEPT PHARMACOL,MANSFIELD RD OXFORD OX1 3QT OXON ENGLAND
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 2, volume: 98, anno: 1994,
pagine: 125 - 131
SICI:
0303-7207(1994)98:2<125:CATACP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEA-URCHIN EGGS; RELEASE CHANNEL; INOSITOL TRISPHOSPHATE; 2ND-MESSENGER ENZYME; CA-2+ RELEASE; CA2+ RELEASE; EXPRESSION; MODULATION; MICROSOMES; METABOLITE;
Keywords:
CYCLIC ADP-RIBOSE; CALCIUM; RYODANINE; CYCLIC GUANOSINE MONOPHOSPHATE; CELL SIGNALING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Galione, "CYCLIC ADP-RIBOSE, THE ADP-RIBOSYL CYCLASE PATHWAY AND CALCIUM SIGNALING", Molecular and cellular endocrinology, 98(2), 1994, pp. 125-131

Abstract

Cyclic adenosine diphosphate-ribose, an endogenous metabolite of nicotinamide adenine dinucleotide was first characterized as a potent Ca2mobilizing agent in sea urchin eggs. Mounting evidence points to it being an endogenous activator of Ca2+-induced Ca2+ release by non-skeletal muscle ryanodine receptors in several invertebrate and mammalian cell types. Cyclic adenosine diphosphate-ribose is synthesized by adenosine diphosphate-ribosyl cyclases, which have been found to be widespread enzymes. Recent data suggests that cyclic adenosine diphosphate-ribose may function as a second messenger in sea urchin eggs at fertilization and in stimulus secretion coupling in pancreatic beta-cells. A second messenger role for cyclic adenosine diphosphate-ribose requires that its intracellular levels be under the control of extracellular stimuli. Another second messenger, cGMP, stimulates the synthesis of cyclic adenosine diphosphate-ribose from nicotinamide adenine dinucleotide by activating the adenosine diphosphate-ribosyl cyclase pathway in sea urchin eggs and egg homogenates, suggesting that cyclic adenosine diphosphate-ribose may be an intracellular messenger for cell surface receptors or nitric oxide, which activate cGMP-producing guanylate cyclases. Cyclic adenosine diphosphate-ribose may have a similar role to inositol trisphosphate in controlling intracellular calcium signalling with these two calcium-mobilizing second messengers activating ryanodine receptors and inositol trisphosphate receptors respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:30:10