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Titolo:
ALCOHOLISM AND CANCER OF THE LARYNX - A CASE-CONTROL STUDY IN WESTERNWASHINGTON (UNITED-STATES)
Autore:
HEDBERG K; VAUGHAN TL; WHITE E; DAVIS S; THOMAS DB;
Indirizzi:
FRED HUTCHINSON CANC RES INST,MP 474,1124 COLUMBIA ST SEATTLE WA 98104 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED SEATTLE WA 98195
Titolo Testata:
CCC. Cancer causes & control
fascicolo: 1, volume: 5, anno: 1994,
pagine: 3 - 8
SICI:
0957-5243(1994)5:1<3:AACOTL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Keywords:
ALCOHOL; ALCOHOLISM; LARYNGEAL CANCER; LARYNX; UNITED STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
K. Hedberg et al., "ALCOHOLISM AND CANCER OF THE LARYNX - A CASE-CONTROL STUDY IN WESTERNWASHINGTON (UNITED-STATES)", CCC. Cancer causes & control, 5(1), 1994, pp. 3-8

Abstract

Alcohol consumption is a well-known risk factor for laryngeal cancer. To determine whether alcoholism, as measured by responses to the Michigan alcoholism screening test (MAST), is a risk factor for laryngeal cancer independent of alcohol consumption, we analyzed data from a population-based case-control study. Personal interviews were conducted with 235 patients (81 percent response rate) with laryngeal cancer diagnosed from September 1983 through February 1987, who were residents ofthe Seattle metropolitan area. A total of 547 controls frequency-matched by age and gender, selected by random-digit dialing, were interviewed (75 percent response rate). When considered in a multivariate model, independent risk factors for laryngeal cancer included: alcohol consumption (42 or more drinks/wk compared with seven or less drinks/wk: odds ratio [OR] = 3.1, 95 percent confidence interval [CI] = 1.2-7.9);cigarette use (40 or more cigarettes/day compared with never-smoked: OR = 23.1, CI = 9.452.6); and weighted positive responses to the MAST (score of five or more compared with score of zero: OR = 1.9, CI = 1.1-3.4). Possible explanations for the association between alcoholism and laryngeal cancer are that a measure of alcoholism improves the accuracy of assessment of alcohol consumption, that alcoholism is associated with a pattern of alcohol consumption that increases the risk of laryngeal cancer, or that alcoholism may be a marker for host susceptibility to the carcinogenic effects of alcohol.

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Documento generato il 26/09/20 alle ore 14:44:55