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Titolo:
FUNCTIONAL COUPLING BETWEEN ENDOTHELIN RECEPTORS AND MULTIPLE G-PROTEINS IN RAT-HEART MYOCYTES
Autore:
SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Receptors & channels
fascicolo: 4, volume: 1, anno: 1993,
pagine: 295 - 304
SICI:
1060-6823(1993)1:4<295:FCBERA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; STIMULATED PHOSPHOINOSITIDE HYDROLYSIS; VENTRICULAR MYOCYTES; PHOSPHOLIPASE-C; PERTUSSIS; CLONING; EXPRESSION; ANTAGONIST; PHOSPHATIDYLINOSITOL; ACCUMULATION;
Keywords:
ENDOTHELINS; GTPASE; FUNCTIONAL COUPLING; SARAFOTOXINS; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Sokolovsky, "FUNCTIONAL COUPLING BETWEEN ENDOTHELIN RECEPTORS AND MULTIPLE G-PROTEINS IN RAT-HEART MYOCYTES", Receptors & channels, 1(4), 1993, pp. 295-304

Abstract

Binding data point to the coexistence of three endothelin receptors (ET-R) in rat heart myocytes. Induction of phosphoinositide hydrolysis in this preparation by endothelins (ET-1 and ET-3) or sarafotoxins (SRTX-b and SRTX-c) was demonstrated by measurement of labeled inositol phosphate generation. Pertussis toxin (PT) enhanced the induction of phosphoinositide hydrolysis by all four peptides. The process seems to be mediated by at least two heterotrimeric G-proteins, the one sensitive and the other insensitive to PT. Measurement of GTPase activity induced in rat myocytes clearly indicates for the first time the direct functional coupling between ET-R and a G-protein. These GTPase activity experiments provide evidence that phosphoinositide hydrolysis is stimulated via functional coupling between the endothelin receptor of the ET(A)-R subtype and a PT-insensitive G-protein, Gq/11. The involvement of PT-sensitive G-proteins, i.e. Gi-like and/or Go-like proteins, in the signal transduction pathways of ETs and SRTXs is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:25:35