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Titolo:
DECREASED ACETYLATION OF ISONIAZID IN CHRONIC-RENAL-FAILURE
Autore:
KIM YG; SHIN JG; SHIN SG; JANG IJ; KIM SG; LEE JS; HAN JS; CHA YN;
Indirizzi:
SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL,CLIN PHARMACOL UNIT,28 YEONGUNDONG,CHONGRO GU SEOUL 110799 SOUTH KOREA SEOUL NATL UNIV,COLL MED,DEPT PHARMACOL,CLIN PHARMACOL UNIT,28 YEONGUNDONG,CHONGRO GU SEOUL 110799 SOUTH KOREA SEOUL NATL UNIV,COLL MED,DEPT INTERNAL MED SEOUL SOUTH KOREA INHA UNIV,COLL MED,DEPT PHARMACOL INCHON PEOPLES R CHINA
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 6, volume: 54, anno: 1993,
pagine: 612 - 620
SICI:
0009-9236(1993)54:6<612:DAOIIC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL PHARMACOKINETICS; MAINTENANCE HEMODIALYSIS; TUBERCULOSIS; METABOLISM; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y.G. Kim et al., "DECREASED ACETYLATION OF ISONIAZID IN CHRONIC-RENAL-FAILURE", Clinical pharmacology and therapeutics, 54(6), 1993, pp. 612-620

Abstract

Pharmacokinetic parameters of isoniazid obtained from 37 normal subjects were compared with parameters obtained from 14 patients with chronic renal failure. In the 29 normal rapid acetylators and eight normal slow acetylators, the mean plasma half-life values of isoniazid were 1.54 +/- 0.31 and 3.68 +/-0.59 hours, respectively. The plasma half-life values of isoniazid in patients with chronic renal failure varied widely from 1.30 to 10.13 hours, but the values were significantly longer than those of normal subjects. Because isoniazid clearance is governed mainly by hepatic metabolism, such a significant prolongation of plasma half-life of isoniazid was unexpected; thus the pharmacokinetics of isoniazid were reevaluated in the same patients with chronic renal failure after the kidney transplantation. After successful kidney transplantation, the shortening of isoniazid half-life was pronounced and the nonrenal clearance was markedly increased. These findings indicatethat decreased isoniazid clearance in chronic renal failure is causedin minor part by the decreased renal excretion of isoniazid and in major part by the depressed hepatic N-acetylation of isoniazid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:41:17