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Titolo:
THE HYPOTENSIVE ACTION OF CAPTOPRIL AND ENALAPRIL IS NOT PROSTACYCLINDEPENDENT
Autore:
GERBER JG; FRANCA G; BYYNY RL; LOVERDE M; NIES AS;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,DIV CLIN PHARMACOL,C-237,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DIV GEN INTERNAL MED DENVER CO 80262
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 5, volume: 54, anno: 1993,
pagine: 523 - 532
SICI:
0009-9236(1993)54:5<523:THAOCA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; ANTI-INFLAMMATORY DRUGS; BLOOD-PRESSURE CONTROL; ESSENTIAL-HYPERTENSION; SULFHYDRYL-GROUPS; INDOMETHACIN; INHIBITORS; SULINDAC; PROSTAGLANDIN-I2; VASODILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Gerber et al., "THE HYPOTENSIVE ACTION OF CAPTOPRIL AND ENALAPRIL IS NOT PROSTACYCLINDEPENDENT", Clinical pharmacology and therapeutics, 54(5), 1993, pp. 523-532

Abstract

Angiotensin converting enzyme inhibitors have been proposed to have aprostaglandin-dependent component to their hypotensive action. The aim of this study was to assess whether the structurally dissimilar angiotensin converting enzyme inhibitors captopril and enalapril stimulatethe synthesis of prostacyclin, whether their hypotensive action is blunted by indomethacin, and whether these biochemical or physiologic parameters differ for the two drugs, in white subjects with essential hypertension. Twelve patients were enrolled and 11 finished the study. The study consisted of a double blind, randomized, double-crossover design. All patients received either placebo or 50 mg indomethacin twice a day for 3 weeks; after 1 week of placebo or indomethacin either 50 mg captopril or 10 mg enalapril twice a day was added and continued for2 weeks. Each patient received every possible combination. Neither captopril nor enalapril stimulated prostacyclin production as determinedby measurement of the urinary excretion rate of its main enzymatic metabolite, 2,3-dinor-6-keto-prostaglandin F1alpha. Although indomethacin reduced the urinary excretion of the enzymatic metabolite of prostacyclin by more than 50%, it did not influence the hypotensive effect ofcaptopril or enalapril. We conclude that neither captopril nor enalapril have a significant prostacyclin-dependent component to their hypotensive action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 04:49:59