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Titolo:
PREVALENCE OF AFFECTIVE-DISORDER IN THE CHILD AND ADOLESCENT OFFSPRING OF A SINGLE KINDRED - A PILOT-STUDY
Autore:
TODD RD; REICH W; REICH T;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 2, volume: 33, anno: 1994,
pagine: 198 - 207
SICI:
0890-8567(1994)33:2<198:POAITC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; LYMPHOBLASTOID CELL-LINES; DIAGNOSES; PSYCHOPATHOLOGY; PARENTS; ILLNESS;
Keywords:
BIPOLAR AFFECTIVE DISORDER; FAMILY STUDY; CHILDHOOD DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Todd et al., "PREVALENCE OF AFFECTIVE-DISORDER IN THE CHILD AND ADOLESCENT OFFSPRING OF A SINGLE KINDRED - A PILOT-STUDY", Journal of the American Academy of Child and Adolescent Psychiatry, 33(2), 1994, pp. 198-207

Abstract

Objective: The study determined the prevalence of psychiatric disorders among the child and adolescent offspring of an extended family identified through a proband with bipolar affective disorder. Method: All of the not mentally retarded offspring (ages 6 to 17 years) of a single extended bipolar affective disorder pedigree were studied. Data regarding psychiatric diagnoses, intelligence, school achievement, temperament, and family functioning were collected using structured and standardized instruments. Results: When the child and adolescent offspring were stratified by degree of genetic relationship to an adult with an affective disorder, there were no differences in demographic variables, IQ, school achievement, or most temperamental and family characteristics. In contrast, there were increases in the rates of affective disorders and disruptive behavior disorders in the off spring that correlated with the degree of genetic relationship to an affected adult. Conclusions: The risk of developing an early onset affective disorder is correlated with the degree of genetic relatedness to affected adults inthis single, extended family. This pilot study demonstrates that the inclusion of extended relatives in high-risk studies can enhance the discrimination of genetic and environmental contributions to the development of affective disorders.

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Documento generato il 10/07/20 alle ore 17:57:55