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Titolo:
KANAMYCIN DEPLETES COCHLEAR POLYAMINES IN THE DEVELOPING RAT
Autore:
HENLEY CM;
Indirizzi:
BAYLOR COLL MED,DEPT OTORHINOLARYNGOL COMMUN SCI & PHARMACOL,1 BAYLORPL HOUSTON TX 77030
Titolo Testata:
Otolaryngology and head and neck surgery
fascicolo: 1, volume: 110, anno: 1994,
pagine: 103 - 109
SICI:
0194-5998(1994)110:1<103:KDCPIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC DISTORTION PRODUCTS; REVERSIBLE CEREBRAL-ISCHEMIA; EAR ORNITHINE DECARBOXYLASE; INDUCED HEARING-LOSS; ALPHA-DIFLUOROMETHYLORNITHINE; AMINOGLYCOSIDE OTOTOXICITY; AUDITORY FUNCTION; GUINEA-PIGS; METABOLISM; GENTAMICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Henley, "KANAMYCIN DEPLETES COCHLEAR POLYAMINES IN THE DEVELOPING RAT", Otolaryngology and head and neck surgery, 110(1), 1994, pp. 103-109

Abstract

Developing mammals are more sensitive to aminoglycoside antibiotics and other ototoxic agents than adults, with maximum sensitivity occurring during the period of anatomic and functional maturation of the cochlea. For the aminoglycoside antibiotics, the hypersensitive period in rats occurs during the second and third postnatal weeks. Toxicity is initially expressed as outer hair cell (OHC) damage in the high-frequency, basal region of the cochlea. Distortion-product otoacoustic emissions (DPOAEs), physiologic measures of OHC function, are particularly sensitive to aminoglycoside exposure during the period of rapid cochlear physiologic development. Toxicity is characterized by increased DPOAE thresholds and decreased amplitudes. The mechanism of developmental sensitivity to aminoglycosides is unknown. A potential biochemical target of aminoglycosides is the ornithine decarboxylase (ODC)-polyamine pathway. ODC activity is elevated in the developing rat cochlea, aminoglycosides inhibit cochlear ODC in developing rats, and alpha-difluoromethylornithine (a specific ODC inhibitor) impairs development of cochlear function. In the present study we demonstrate an incomplete polyamine response to aminoglycoside damage, characterized by inhibition ofthe polyamines spermidine and spermine and accumulation of putrescinein the organ of Corti, Aminoglycoside inhibition of polyamine synthesis may mediate developmental ototoxic hypersensitivity by interfering with developmental and repair processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:23:47