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Titolo:
SERUM ESTROGEN AND ANDROGEN LEVELS FOLLOWING TREATMENT FOR CERVICAL-CANCER
Autore:
INSKIP PD; EBY NL; COOKFAIR D; FREEDMAN RS; RICHARDSON GS; WACTAWSKIWENDE J; HOOVER RN; BOICE JD;
Indirizzi:
NCI,6130 EXECUT BLVD,EPN,ROOM 408 ROCKVILLE MD 20852 NCI,DIV CANC ETIOL,EPIDEMIOL & BIOSTAT PROGRAM BETHESDA MD 20892 GERMAN CANC RES CTR,INST EPIDEMIOL & BIOMETRY W-6900 HEIDELBERG GERMANY SUNY BUFFALO,SCH MED,DEPT SOCIAL & PREVENT MED BUFFALO NY 14260 SUNY BUFFALO,SCH MED,DEPT GYNECOL & OBSTET BUFFALO NY 00000 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT GYNECOL HOUSTON TX 77030 MASSACHUSETTS GEN HOSP,VINCENT GYNECOL SERV BOSTON MA 00000
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 1, volume: 3, anno: 1994,
pagine: 37 - 45
SICI:
1055-9965(1994)3:1<37:SEAALF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-MENOPAUSAL WOMEN; POSTMENOPAUSAL WOMEN; ENDOMETRIAL CANCER; BREAST-CANCER; CARDIOVASCULAR-DISEASE; ENDOCRINE FUNCTION; CIGARETTE-SMOKING; STEROID LEVELS; OVARIAN; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
P.D. Inskip et al., "SERUM ESTROGEN AND ANDROGEN LEVELS FOLLOWING TREATMENT FOR CERVICAL-CANCER", Cancer epidemiology, biomarkers & prevention, 3(1), 1994, pp. 37-45

Abstract

Endogenous sex hormones seem to influence the risk of several common and debilitating diseases. With a view toward better understanding theeffects of surgical removal of the ovaries and high-dose pelvic radiotherapy on plasma sex hormone levels, we measured estrogen and androgen concentrations cross-sectionally among 147 women who had been treated for cervical cancer 0.3-18.5 years previously. Pelvic radiotherapy (mean dose to ovaries, 50 Gy) and bilateral ovariectomy were associatedwith similarly reduced hormone concentrations relative to levels among nonirradiated women with intact ovaries, most of whom had had early-stage disease and were treated by hysterectomy. There was little evidence that radiotherapy in addition to ovariectomy further lowered concentrations below levels associated with ovariectomy alone, such as might be expected if radiation was suppressing adrenal endocrine function. Among women age 50 years or older at the time of blood drawing, the removal or irradiation of the ovaries was associated with approximately45% lower concentrations of estradiol (mean ratio [MR], 0.55; 95% confidence interval [CI], 0.32-0.95) and testosterone (MR, 0.57; 95% CI, 0.32-0.99), and 25-30% lower concentrations of estrone (MR, 0.69; 95% CI, 0.44-1.09) and androstenedione (MR, 0.76; 95% CI, 0.47-1.23), relative to the hysterectomy-only group. Among women younger than 50, ovariectomy and radiotherapy, alone or in combination, were associated with 83% lower estradiol concentrations (MR, 0.17; 95% CI, 0.09-0.31), 46% lower estrone concentrations (MR, 0.54; 95% CI, 0.37-0.81), 23% lower androstenedione concentrations (MR, 0.77; 95% CI, 0.57-1.04), and 14% lower testosterone levels (MR, 0.86; 95% CI, 0.64-1.15). A possible mechanism for the reductions among postmenopausal women involves effects on androgen-producing cells in the ovary, which retain secretory function after menopause.

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Documento generato il 15/07/20 alle ore 08:44:16