Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TRANSIENT DECREASE OF BINDING OF INSULIN TO PLATELETS IN ACUTE ISCHEMIC-HEART-DISEASE
Autore:
KAHN NN; BAUMAN WA; SINHA AK;
Indirizzi:
VET AFFAIRS MED CTR,SPINAL CORD DAMAGE RES CTR,ROOM 1E-15,1130 W KINGSBRIDGE RD BRONX NY 10468 VET AFFAIRS MED CTR,SPINAL CORD DAMAGE RES CTR BRONX NY 10468 MT SINAI MED CTR,DEPT MED NEW YORK NY 10029 MONTEFIORE MED CTR,DEPT MED BRONX NY 10467
Titolo Testata:
The American journal of the medical sciences
fascicolo: 1, volume: 307, anno: 1994,
pagine: 21 - 26
SICI:
0002-9629(1994)307:1<21:TDOBOI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-E1/I2 RECEPTOR ACTIVITY; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; PROSTACYCLIN; ACTIVATION; MEMBRANE;
Keywords:
PROSTAGLANDIN (PG) E(1); PROTACYLIN (PG) I-2; PLATELETS; INSULIN; ACUTE ISCHEMIC HEART DISEASE; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N.N. Kahn et al., "TRANSIENT DECREASE OF BINDING OF INSULIN TO PLATELETS IN ACUTE ISCHEMIC-HEART-DISEASE", The American journal of the medical sciences, 307(1), 1994, pp. 21-26

Abstract

The specific binding sites of I-125-insulin in platelets from nondiabetic patients with acute myocardial infarction and unstable angina pectoris was significantly decreased (192 +/- 84/cell) during the acute ischemic condition when compared with normal platelets (496 +/- 76/ cell; p < 0.001, n = 9). A relatively low mean plasma insulin level (20 mu U/mL) with an elevated mean glucose level (130 mg/dL) was noted. Thedecreased binding of insulin and the relatively low mean plasma insulin level during the acute ischemic condition improved into the normal range during 8 to 12 weeks of recuperation. The decrease of insulin binding sites in the acute phase and their subsequent increase during recovery were directly related to the hormone-induced increase in sensitivity to prostaglandin E(1) through the stimulation of adenosine 3',5'-cyclic monophosphate formation in platelets by the prostanoid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:40:31