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Titolo: PARTIAL TRISOMY OF 3Q DETECTED BY CHROMOSOME PAINTING IN A CASE OF JUVENILE CHRONIC MYELOMONOCYTIC LEUKEMIA
Autore: MICHALOVA K; BARTSCH O; STARY J; JELINEK J; WIEGANT J; BUBANSKA E;
- Indirizzi:
- CHARLES UNIV,FAC MED 1,DEPT MED 3,U NEMOCNICE 1 12821 PRAGUE 2 CZECH REPUBLIC CHARLES UNIV,FAC MED 2,DEPT PEDIAT 2 PRAGUE CZECH REPUBLIC CHARLES UNIV,INST HEMATOL & BLOOD TRANSF PRAGUE CZECH REPUBLIC MED ACAD CARL GUSTAV CARUS,INST CLIN GENET DRESDEN GERMANY LEIDEN UNIV,SLYVIUS LAB,DEPT CYTOCHEM & CYTOMETRY LEIDEN NETHERLANDS DEPT PEDIAT BANSKA BYSTRICA SLOVAKIA
- Titolo Testata:
- Cancer genetics and cytogenetics
fascicolo: 1,
volume: 71,
anno: 1993,
pagine: 67 - 70
- SICI:
- 0165-4608(1993)71:1<67:PTO3DB>2.0.ZU;2-I
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- CYTOGENETICS;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 11
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- K. Michalova et al., "PARTIAL TRISOMY OF 3Q DETECTED BY CHROMOSOME PAINTING IN A CASE OF JUVENILE CHRONIC MYELOMONOCYTIC LEUKEMIA", Cancer genetics and cytogenetics, 71(1), 1993, pp. 67-70
Abstract
Juvenile chronic myelomonocytic leukemia (JCMMoL) is a rare disease with no specific type of chromosome aberration yet delineated. We report a P-year-old boy who had in his leukemic bone marrow (BM) and peripheral blood (PB) cells the 46,XY,der(15)t(3;15)(q13.1;q26) karyotype. Phytohemagglutinin (PHA)-stimulated lymphocytes of peripheral blood hada normal 46,XY karyotype. The origin of the duplicated part of 3q wasproved by fluorescence in situ hybridization (FISH) with the pHSR(satIII 15p) DNA probe and a chromosome 3-specific DNA library (i.e., chromosome painting). The chromosome finding in our case provides furtherproof of the close relationship between the rearrangement in region 3q13-->3q26 and the pathogenesis of acute myeloid leukemia (AML). Our patient has transformed into erythroleukemia [M6 according to the French-American-British (FAB) classification] during the course of the disease.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:30:19