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Titolo:
DEHYDROEPIANDROSTERONE-SULFATE AND ANOVULATION INCREASE SERUM INHIBINAND AFFECT FOLLICULAR FUNCTION DURING ADMINISTRATION OF GONADOTROPINS
Autore:
HANING RV; HUA JJ; HACKETT RJ; WHEELER CA; FRISHMAN GN; SEIFER DB; DAHL CA; BURGER HG;
Indirizzi:
WOMEN & INFANTS HOSP RHODE ISL,DEPT OBSTET & GYNECOL,101 DUDLEY ST PROVIDENCE RI 02905 BROWN UNIV PROVIDENCE RI 02905 PRINCE HENRYS INST MED RES MELBOURNE VIC AUSTRALIA
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 1, volume: 78, anno: 1994,
pagine: 145 - 149
SICI:
0021-972X(1994)78:1<145:DAAISI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC-OVARY-SYNDROME; METABOLIC-CLEARANCE RATE; HORMONE AGONIST; HIRSUTE WOMEN; INVITRO FERTILIZATION; OVULATION INDUCTION; STEROID-SECRETION; TESTOSTERONE; SUPPRESSION; LEUPROLIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Haning et al., "DEHYDROEPIANDROSTERONE-SULFATE AND ANOVULATION INCREASE SERUM INHIBINAND AFFECT FOLLICULAR FUNCTION DURING ADMINISTRATION OF GONADOTROPINS", The Journal of clinical endocrinology and metabolism, 78(1), 1994, pp. 145-149

Abstract

To test the hypothesis that testosterone (T) derived from circulatingdehydroepiandrosterone sulfate (DS) or produced in excess within the anovulatory ovary is a follicular regulator capable of stimulating inhibin secretion, DS and inhibin were determined by RIA in residual serum samples from in vitro fertilization cycles and analyzed along with other parameters using analysis of variance and stepwise multiple linear regression after log transformation of the RIA data. It was predicted that the serum concentration of inhibin would be higher in women with anovulation than in normal subjects and that the serum inhibin concentration would have a positive regression coefficient on the serum DS concentration. The serum concentrations of inhibin (P < 0.01) and estradiol (P < 0.001) on the day of hCG treatment were higher in women with anovulation than in normal subjects, as was the number of oocytes retrieved (P < 0.001). The FSH and LH doses (both P < 0.005) and age (P < 0.001) were significantly lower, and the average duration of gonadotropin therapy was 1 day shorter (P < 0.001) in anovulatory patients. There was no significant difference in serum DS (P > 0.2).Regression analysis showed that serum inhibin was positively related to the number of oocytes (P < 0.001) and serum DS (P = 0.05), with an increase in anovulatory subjects (P < 0.025). The duration of treatment with gonadotropins was related positively to the patient's age (P < 0.001) and negatively to serum DS (P < 0.025), with a decrease in anovulatory subjects (P < 0.025). The number of oocytes obtained was negatively related to age (P < 0.001) and positively to serum DS (P < 0.005). These data are consistent with a stimulatory effect of follicular T derived from either circulating DS or the anovulatory ovary, which affects the secretion of inhibin, the duration of gonadotropin treatment, and the number of oocytes retrieved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:23:41