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Titolo:
CSF BIOCHEMISTRIES, GLUCOSE-METABOLISM, AND DIURNAL ACTIVITY RHYTHMS IN ALCOHOLIC, VIOLENT OFFENDERS, FIRE SETTERS, AND HEALTHY-VOLUNTEERS
Autore:
VIRKKUNEN M; RAWLINGS R; TOKOLA R; POLAND RE; GUIDOTTI A; NEMEROFF C; BISSETTE G; KALOGERAS K; KARONEN SL; LINNOILA M;
Indirizzi:
NIAAA,DIV INTRAMURAL CLIN & BIOL RES,CLIN STUDIES LAB,BLDG 10,ROOM 3C103 BETHESDA MD 20892 NIAAA,DIV INTRAMURAL CLIN & BIOL RES,CLIN STUDIES LAB BETHESDA MD 20892 UNIV HELSINKI,DEPT PSYCHIAT SF-00180 HELSINKI FINLAND UNIV HELSINKI,DEPT CLIN CHEM SF-00100 HELSINKI FINLAND UCLA,HARBOR MED CTR,DIV BIOL PSYCHIAT TORRANCE CA 90509 EMORY UNIV,DEPT PSYCHIAT ATLANTA GA 30322 DUKE UNIV,MED CTR,DEPT PSYCHIAT DURHAM NC 27710 FIDIA GEORGETOWN NEUROSCI INST WASHINGTON DC 00000 NIMH,INTRAMURAL RES PROGRAM,CLIN NEUROENDOCRINOL BRANCH BETHESDA MD 20892
Titolo Testata:
Archives of general psychiatry
fascicolo: 1, volume: 51, anno: 1994,
pagine: 20 - 27
SICI:
0003-990X(1994)51:1<20:CBGADA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CEREBROSPINAL-FLUID MONOAMINE; 5-HYDROXYINDOLEACETIC ACID; SECRETION; TESTOSTERONE; DEPRESSION; BRAIN; SCHIZOPHRENIA; NEUROPEPTIDES; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Virkkunen et al., "CSF BIOCHEMISTRIES, GLUCOSE-METABOLISM, AND DIURNAL ACTIVITY RHYTHMS IN ALCOHOLIC, VIOLENT OFFENDERS, FIRE SETTERS, AND HEALTHY-VOLUNTEERS", Archives of general psychiatry, 51(1), 1994, pp. 20-27

Abstract

Background: There is an extensive literature describing a central serotonin deficit in alcoholic, impulsive, violent offenders and fire setters. In the present study, we investigated biochemical concomitants of impulsivity and aggressiveness, and the physiological consequences of reduced central serotonin turnover. Methods: Forty-three impulsive and 15 nonimpulsive alcoholic offenders and 21 healthy volunteers were studied in the forensic psychiatry ward of a university psychiatric department. The subjects underwent lumbar punctures and oral glucose andaspartame challenges, and their diurnal activity rhythm was measured with physical activity monitors. Discriminant function analyses were used to investigate psychophysiological and biochemical concomitants ofaggressive and impulsive behaviors. Results: Alcoholic, impulsive offenders with antisocial personality disorder had low mean cerebrospinalfluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and corticotropin levels and high mean CSF testosterone concentrations. Compared with healthy volunteers, they showed increased physical activity during the daytime. Alcoholic, impulsive offenders with intermittent explosive disorder had a low mean CSF 5-HIAA concentration and blood glucose nadir after an oral glucose challenge, and desynchronized diurnal activity rhythm. Healthy volunteers had mean CSF 5-HIAA concentrations that were intermediate between those of alcoholic, impulsive and non-impulsive offenders. Alcoholic, nonimpulsive offenders had a significantly higher mean CSF S-HIAA concentration than all the other groups, including healthy volunteers. Conclusions: In the present sample, a low CSF 5-HIAA concentration was primarily associated with impulsivity and high CSF testosterone concentration, with aggressiveness or interpersonal violence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:16:29