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Titolo:
GREEN TEA AND SKIN - ANTICARCINOGENIC EFFECTS
Autore:
MUKHTAR H; KATIYAR SK; AGARWAL R;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SKIN DIS RES CTR,DEPT DERMATOL,2074 ABINGTON RD CLEVELAND OH 44106
Titolo Testata:
Journal of investigative dermatology
fascicolo: 1, volume: 102, anno: 1994,
pagine: 3 - 7
SICI:
0022-202X(1994)102:1<3:GTAS-A>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENCAR MOUSE SKIN; TUMOR INITIATION; MULTISTAGE CARCINOGENESIS; DRINKING-WATER; HAIRLESS MICE; POLYPHENOLS; INHIBITION; PROMOTION; RADIATION; FRACTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
H. Mukhtar et al., "GREEN TEA AND SKIN - ANTICARCINOGENIC EFFECTS", Journal of investigative dermatology, 102(1), 1994, pp. 3-7

Abstract

Because of its special aroma, green tea is a popular beverage consumed by some human populations worldwide. In recent years, many laboratory studies have shown that in a variety of animal tumor bioassay systems the administration of green tea, specifically the polyphenolic fraction isolated from green tea leaves (green tea polyphenols), affords protection against cancer induction. In mouse skin tumor bioassay systems, topical application on of green tea polyphenols to result in protection against skin has been a) 3-methylcholanthrene-induced skin tumorigenicity, b) 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin tumor initiation, c) 12-O-tetradecanoylphorbol-13-acetate and other tumor promoters caused tumor promotion in DMBA-initiated skin, and d) benzoyl peroxide- and 4-nitroquinoline N-oxide caused enhanced malignant progression of nonmalignant lesions. Green tea extract has also been shown to cause partial regression of established skin papillomas in mouse. Similarly, chronic oral feeding of green tea polyphenols or water extract of green tea has also been shown to result in the protection against both chemical carcinogen- and ultraviolet B radiation-induced skin tumorigenicity. Collectively these data suggest that green tea possesses significant chemopreventive effect against each stage of carcinogenesis, and that it may be useful against inflammatory responses associated with the exposure of skin to chemical tumor promoters as well as tosolar radiation. Available data regarding the mechanism by which green tea affords these diversified effects is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:15:54