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Titolo:
PLASMA-LEVELS AND EFFICACY OF IMIPRAMINE TREATMENT FOR ENURESIS
Autore:
FRITZ GK; ROCKNEY RM; YEUNG AS;
Indirizzi:
BROWN UNIV,RHODE ISL HOSP,593 EDDY ST PROVIDENCE RI 02903
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 1, volume: 33, anno: 1994,
pagine: 60 - 64
SICI:
0890-8567(1994)33:1<60:PAEOIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD ENURESIS; SERUM;
Keywords:
ENURESIS; IMIPRAMINE; SERUM LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
G.K. Fritz et al., "PLASMA-LEVELS AND EFFICACY OF IMIPRAMINE TREATMENT FOR ENURESIS", Journal of the American Academy of Child and Adolescent Psychiatry, 33(1), 1994, pp. 60-64

Abstract

Objective: To determine the relationship between serum drug level andtreatment efficacy in enuretic children treated with imipramine (IMI). Method: Eighteen children with primary nocturnal enuresis recruited from an ambulatory enuresis clinic population were the subjects of thestudy. After a baseline period of 2 weeks, children received placebo for 1 week followed by treatment with IMI in increasing dosages (1.0 mg/kg, 1.5 mg/kg, 2.0 mg/kg, and 2.5 mg/kg), each dosage being given for 2 weeks. Steady state IMI and desipramine levels were determined in each child for each dosage. Medication response ([drug % dryness - placebo % dryness] divided by [100% - placebo % dryness]) was determined for each dosing interval. Results: Average dryness increased from 27.8% on placebo to 73% with 2.5 mg/kg of IMI. The overall correlation between medication response and combined serum level was .26 (p < .05). Side effects were monitored throughout the study and were found to be rare. Conclusions: The efficacy of IMI over placebo in reducing the frequency of nocturnal enuresis in children was confirmed. Efficacy was moderately but significantly related to increasing mg/kg dose. A higherserum level tended to be associated with a better response, but therewas at least 700% variation in serum level between subjects at every dosage. Monitoring serum levels of imipramine in children with idiopathic functional nocturnal enuresis treated with that medication has a limited but real usefulness in clinical management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:23:14