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Titolo:
REGULATION OF CHOLESTEROL-SYNTHESIS AND ESTERIFICATION IN PRIMARY CULTURES OF MACROPHAGES FOLLOWING UPTAKE OF CHYLOMICRON REMNANTS
Autore:
YU KCW; MAMO JCL;
Indirizzi:
UNIV WESTERN AUSTRALIA,DEPT MED,BOX X2213 PERTH WA 6009 AUSTRALIA UNIV WESTERN AUSTRALIA,DEPT PHYSIOL NEDLANDS WA 6907 AUSTRALIA UNIV WESTERN AUSTRALIA,DEPT MED NEDLANDS WA 6907 AUSTRALIA
Titolo Testata:
Biochemistry and molecular biology international
fascicolo: 1, volume: 41, anno: 1997,
pagine: 33 - 39
SICI:
1039-9712(1997)41:1<33:ROCAEI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; BETA-VLDL; RECEPTOR;
Keywords:
CHYLOMICRON REMNANTS; LOW-DENSITY-LIPOPROTEINS; BETA-VERY-LOW-DENSITY-LIPOPROTEINS; CHOLESTEROL SYNTHESIS; CHOLESTEROL ESTERIFICATION; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K.C.W. Yu e J.C.L. Mamo, "REGULATION OF CHOLESTEROL-SYNTHESIS AND ESTERIFICATION IN PRIMARY CULTURES OF MACROPHAGES FOLLOWING UPTAKE OF CHYLOMICRON REMNANTS", Biochemistry and molecular biology international, 41(1), 1997, pp. 33-39

Abstract

The effects of chylomicron remnants (CR), beta-very-low-density-lipoproteins (beta-VLDL) and low-density-lipoproteins (LDL) on intracellular cholesterol synthesis and esterification in primary rabbit macrophages was determined by assaying for HMG-CoA reductase activity and cholesterol esterification. At physiological cholesterol concentrations, both CR and LDL inhibited cholesterol synthesis by almost 60% while beta-VLDL was less potent achieving only 30% inhibition. Cholesterol esterification rates were increased four-fold by CR and LDL, whereas beta-VLDL increased esterification 14 times above controls. Qualitatively, the effect of CR on cholesterol synthesis and esterification in rabbit macrophages differs from observations in transformed macrophage cells. Quantitatively, the enhanced rates of cholesterol esterification and weak inhibition of cholesterol synthesis following beta-VLDL uptake may explain why this lipoprotein rapidly induces foam cell formation in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 14:13:35