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Titolo:
EVALUATION OF THE TUMOR-INITIATING ACTIVITY OF 4-, 5-, 6-, AND 7-FLUOROBENZO[B]FLUORANTHENE IN MOUSE SKIN
Autore:
LAVOIE EJ; CAI ZW; MEEGALLA RL; WEYAND EH;
Indirizzi:
RUTGERS UNIV,COLL PHARM,DEPT PHARMACEUT CHEM,POB 789 PISCATAWAY NJ 08855
Titolo Testata:
Chemico-biological interactions
fascicolo: 2-3, volume: 89, anno: 1993,
pagine: 129 - 139
SICI:
0009-2797(1993)89:2-3<129:EOTTAO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; CHEMICAL CARCINOGENESIS; FLUORINATED DERIVATIVES; BENZO)B>FLUORANTHENE; TUMORIGENICITY; MUTAGENICITY; SUBSTITUTION; METABOLITES; BENZO)J>FLUORANTHENE; BENZO)K>FLUORANTHENE;
Keywords:
FLUORINATED POLYCYCLIC AROMATIC HYDROCARBONS; TUMOR-INITIATION; MOUSE SKIN; BENZO[B]FLUORANTHENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Lavoie et al., "EVALUATION OF THE TUMOR-INITIATING ACTIVITY OF 4-, 5-, 6-, AND 7-FLUOROBENZO[B]FLUORANTHENE IN MOUSE SKIN", Chemico-biological interactions, 89(2-3), 1993, pp. 129-139

Abstract

Benzo[b]fluoranthene and 4-, 5-, 6-, and 7-fluorobenzo[b]fluoranthenewere evaluated for tumor-initiating activity in mouse skin. These fluorinated benzo[b]fluoranthene derivatives were assayed at doses of 400, 120, 40, and 10 nmol per mouse. Similar tumorigenic activity was observed for benzo[b]fluoranthene and 5-fluorobenzo[b]fluoranthene. While4-fluorobenzo[b]fluoranthene did produce a significant tumorigenic response at each dose assayed, substantially fewer tumors per mouse wereobserved compared to benzo[b]fluoranthene at initiator doses at or above 120 nmol. Only moderate tumorigenic activity was observed for 6- and 7-fluorobenzo[b]fluoranthene. Both of these fluorinated derivativeswere significantly less tumorigenic (P < 0.05) than 4-fluorobenzo[b]fluoranthene when administered at initiator doses at or below 120 nmol. These results were unanticipated in view of data which indicate that metabolism of ns-9,10-dihydro-9,10-dihydroxybenzo[b]fluoranthene to trans-9, 10-dihydro-5,9,10-trihydroxybenzo[b]fluoranthene represents a principal activation mechanism of benzo[b]fluoranthene in mouse skin. The potential of fluorine substitution not only to inhibit metabolism, but also to alter the genotoxic activity of those metabolites which doform could explain the tumorigenic activity observed with these fluorinated derivatives of benzo[b]fluoranthene. These data suggest cautionin the interpretation of results based exclusively upon the assumption that the only influence of fluorine substitution is inhibition of the formation of specific metabolites.

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Documento generato il 04/12/20 alle ore 09:24:25