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Titolo:
APOPTOSIS DURING PHOTODYNAMIC THERAPY-INDUCED ABLATION OF RIF-1 TUMORS IN C3H MICE - ELECTRON-MICROSCOPIC, HISTOPATHOLOGIC AND BIOCHEMICAL-EVIDENCE
Autore:
ZAIDI SIA; OLEINICK NL; ZAIM MT; MUKHTAR H;
Indirizzi:
CASE WESTERN RESERVE UNIV,HOSP CLEVELAND,DEPT DERMATOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,HOSP CLEVELAND,DEPT DERMATOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,HOSP CLEVELAND,DEPT RADIOL CLEVELAND OH 44106
Titolo Testata:
Photochemistry and photobiology
fascicolo: 6, volume: 58, anno: 1993,
pagine: 771 - 776
SICI:
0031-8655(1993)58:6<771:ADPTAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S.I.A. Zaidi et al., "APOPTOSIS DURING PHOTODYNAMIC THERAPY-INDUCED ABLATION OF RIF-1 TUMORS IN C3H MICE - ELECTRON-MICROSCOPIC, HISTOPATHOLOGIC AND BIOCHEMICAL-EVIDENCE", Photochemistry and photobiology, 58(6), 1993, pp. 771-776

Abstract

Very little is known about the applicability of the metabolic and biochemical events observed in cell culture systems to in vivo tumor shrinkage following photodynamic therapy (PDT). The purpose of this study was to assess whether PDT induces apoptosis during tumor ablation in vivo. We treated radiation-induced fibrosarcoma (RIF-I) tumors grown inC3H/HeN mice with PDT employing three photosensitizers, Photofrin-II,chloroaluminum phthalocyanine tetrasulfonate, or Pc IV (a promising phthalocyanine developed in this laboratory). Each photosensitizer was injected intraperitoneally and 24 h later the tumors were irradiated with an appropriate wavelength of red light using an argon-pumped dye laser. During the course of tumor shrinkage, the tumors were removed at1, 2, 4 and 10 h post-PDT for DNA fragmentation; histopathologic, andelectron microscopic studies. Markers of apoptosis, viz. the ladder of nucleosome-size DNA fragments, increased apoptotic bodies, and condensation of chromatin material around the periphery of the nucleus, were evident in tumor tissue even 1 h post-PDT; the extent of these changes increased during the later stages of tumor ablation. No changes were observed in tumors given photosensitizer alone or irradiation alone. Our data suggest that the damage produced by in vivo PDT may activateendonucleolysis and chromatin condensation, and that apoptosis is an early event in tumor shrinkage following PDT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:09:28