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Titolo:
EXPRESSION OF PS2 PROTEIN IN BREAST-CANCER
Autore:
CROMBACH G; INGENHORST A; GOHRING UJ; SCHARL A; NEUHAUS W; MOBUS V; SCHAEFFER HJ;
Indirizzi:
UNIV COLOGNE,DEPT OBSTET & GYNECOL,KERPENER STR 34 D-50931 COLOGNE GERMANY UNIV ULM,DEPT OBSTET & GYNECOL ULM GERMANY
Titolo Testata:
Archives of gynecology and obstetrics
fascicolo: 4, volume: 253, anno: 1993,
pagine: 183 - 192
SICI:
0932-0067(1993)253:4<183:EOPPIB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; RESPONSIVE GENE PS2; 5' FLANKING REGION; MESSENGER-RNA; ESTROGEN; MCF-7; CELLS; RECEPTORS; TISSUES;
Keywords:
BREAST CANCER; PROGNOSTIC FACTORS; PS2 PROTEIN; ESTROGEN RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
G. Crombach et al., "EXPRESSION OF PS2 PROTEIN IN BREAST-CANCER", Archives of gynecology and obstetrics, 253(4), 1993, pp. 183-192

Abstract

The pS2 protein was first detected in the oestrogen-dependent breast cancer cell line MCF-7. It may have prognostic value for primary breast cancer, and could be used to predict clinical responsiveness to endocrine therapy. In a retrospective study, the concentrations of pS2 protein were determined in 434 cytosol specimens using an immunoradiometric assay. The median values (4, 6 and 3 ng/mg protein) and the third quartiles (27, 26 and 29 ng/mg) in benign breast tumours (n=17), and inprimary (n=325) and recurrent (n=37) breast carcinomas were of the same order of magnitude. In primary breast cancer, high pS2 values (>26 ng/mg) correlated significantly with a positive oestrogen receptor (ER) status and a high grade of tumour differentiation (P=0.01). As many as 85% of the pS2 positive tumours were ER positive. A marginally significant correlation (P=0.06) was also found between pS2 status and thequantitative expression of the ER. However, the pS2 values in ER positive endometrial carcinomas (n=12) as well as in other benign and malignant genital tumours (n=43) were more than 30 times lower than those measured in breast tumours. The results reveal a close association between pS2 protein and ER status which appears to be limited to breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 14:42:36