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Titolo:
PROSPECTIVE COMPARISON OF UNSTABLE ANGINA VERSUS NON-Q-WAVE MYOCARDIAL-INFARCTION DURING ANTITHROMBOTIC THERAPY
Autore:
COHEN M; XIONG J; PARRY G; ADAMS PC; CHAMBERLAIN D; WIECZOREK I; FOX KAA; MCBRIDE R; CHESEBRO JH; FUSTER V; KELLER C; KRONMAL R; STRAIN J; KELLY A; ALI J; LANCASTER G;
Indirizzi:
HAHNEMANN UNIV,DEPT MED,LIKOFF CARDIOVASC INST,CARDIOL MS-119,BROAD &VINE PHILADELPHIA PA 19102 ROYAL SUSSEX CTY HOSP,DEPT CARDIOL BRIGHTON E SUSSEX ENGLAND ROYAL VICTORIA INFIRM,DEPT CARDIOL NEWCASTLE TYNE TYNE & WEAR ENGLAND UNIV EDINBURGH,CARDIOVASC RES UNIT EDINBURGH MIDLOTHIAN SCOTLAND STAT & EPIDEMIOL RES CORP SEATTLE WA 00000 MAYO CLIN & MAYO FDN ROCHESTER MN 55905 MASSACHUSETTS GEN HOSP,CARDIAC UNIT BOSTON MA 02114 BIOSTAT CTR SEATTLE WA 00000 BETH ISRAEL HOSP NEW YORK NY 00000 MT SINAI HOSP NEW YORK NY 00000 CITY HOSP ELMHURST ELMHURST NY 00000
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 22, anno: 1993,
pagine: 1338 - 1343
SICI:
0735-1097(1993)22:5<1338:PCOUAV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE CORONARY SYNDROMES; MULTICENTER TRIAL; ASPIRIN; TERM; REINFARCTION; PROGNOSIS; PECTORIS; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Cohen et al., "PROSPECTIVE COMPARISON OF UNSTABLE ANGINA VERSUS NON-Q-WAVE MYOCARDIAL-INFARCTION DURING ANTITHROMBOTIC THERAPY", Journal of the American College of Cardiology, 22(5), 1993, pp. 1338-1343

Abstract

Objectives. This study was designed to compare the response of unstable angina and non-Q wave myocardial infarction during treatment with antithrombotic therapy. Background. Antithrombotic therapy is beneficial in patients with these two coronary syndromes. Methods. In a multicenter trial of antithrombotic therapy in unstable angina or non-Q wave myocardial infarction, 358 patients admitted within 48 h of chest painwere randomized to antithrombotic therapy with either 1) aspirin alone, or 2) aspirin plus heparin followed by aspirin plus warfarin, and were prospectively followed up for 12 weeks. Admission cardiac enzyme analyses revealed unstable angina in 268 patients and non-Q wave myocardial infarction in 62. Given an event rate of about 25%, this study has a power of 80% to detect a 50% difference between the two groups. Results. Patients with unstable angina and non-Q wave myocardial infarction were similar with regard to age, gender, coronary risk factors andprior antianginal medication. Primary end points at 12 weeks were recurrent ischemia, infarction and death. [GRAPHICS] In the non-Q wave group, all infarctions and death occurred within the 1st week. Conclusions. Patients with unstable angina or non-Q wave myocardial infarction on antithrombotic therapy have a similar total number of ischemic events by 12 weeks. However, despite maximal medical therapy with antianginal and antithrombotic medication, patients with non-Q wave infarctionhave a significantly higher rate of reinfarction and death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:16:19