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Titolo:
EFFECTS OF LOW-DOSE TRANSDERMAL SCOPOLAMINE ON HEART-RATE-VARIABILITYIN ACUTE MYOCARDIAL-INFARCTION
Autore:
VYBIRAL T; GLAESER DH; MORRIS G; HESS KR; YANG K; FRANCIS M; PRATT CM;
Indirizzi:
HUGH CHATHAM MEM HOSP,PARKWOOD DR ELKIN NC 28621 BAYLOR COLL MED,DEPT MED,CARDIOL SECT HOUSTON TX 77030 BAYLOR COLL MED,DEPT SURG HOUSTON TX 77030 BAYLOR COLL MED,SAKOWITZ COMP LAB HOUSTON TX 00000
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 22, anno: 1993,
pagine: 1320 - 1326
SICI:
0735-1097(1993)22:5<1320:EOLTSO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; CARDIAC PARASYMPATHETIC ACTIVITY; VENTRICULAR EJECTION FRACTION; FREQUENCY-DOMAIN MEASURES; POWER SPECTRAL-ANALYSIS; SUDDEN-DEATH; PERIOD VARIABILITY; ARRHYTHMIC EVENTS; SINUS ARRHYTHMIA; FAILURE SECONDARY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
T. Vybiral et al., "EFFECTS OF LOW-DOSE TRANSDERMAL SCOPOLAMINE ON HEART-RATE-VARIABILITYIN ACUTE MYOCARDIAL-INFARCTION", Journal of the American College of Cardiology, 22(5), 1993, pp. 1320-1326

Abstract

Objectives. We hypothesized that by enhancing parasympathetic activity, low dose transdermal scopolamine would increase heart rate variability after myocardial infarction. Background, Low heart rate variability is associated with increased mortality after acute myocardial infarction. Methods. Conventional time domain heart rate variability was measured from 24-h Holter recordings of 61 consecutive male patients (mean age 58 +/- 10 years, left ventricular ejection fraction 44.7 +/- 15.5%) 6 days (median) after acute myocardial infarction. Patients were then randomly assigned to wear one patch of transdermal scopolamine or a matching placebo patch for 24 h, during which their 24-h heart rate variability was remeasured. Results. Compared with placebo, transdermal scopolamine caused a significant increase in time domain measures of24-h heart rate variability by 26% to 35 % above baseline. Transdermal scopolamine was well tolerated. Conclusions. Low dose transdermal scopolamine safely increases cardiac parasympathetic activity and short-term heart rate variability after acute myocardial infarction. Whetherthe effect of transdermal scopolamine on heart rate variability is a reasonable surrogate for improvement of long-term morbidity and mortality requires an appropriately designed investigation.

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Documento generato il 15/07/20 alle ore 08:16:28