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Titolo:
DOSE-RELATED EFFECTS OF A NEONATAL 6-OHDA LESION ON SKF 38393- AND M-CHLOROPHENYLPIPERAZINE-INDUCED ORAL ACTIVITY RESPONSES OF RATS
Autore:
GONG L; KOSTRZEWA RM; PERRY KW; FULLER RW;
Indirizzi:
E TENNESSEE STATE UNIV,QUILLEN COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 E TENNESSEE STATE UNIV,QUILLEN COLL MED,DEPT PHARMACOL JOHNSON CITY TN 37614 ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
Developmental brain research
fascicolo: 2, volume: 76, anno: 1993,
pagine: 233 - 238
SICI:
0165-3806(1993)76:2<233:DEOAN6>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-1 DOPAMINE-RECEPTORS; BEHAVIORAL-RESPONSES; 6-OHDA-LESIONED RATS; 6-HYDROXYDOPAMINE; AGONIST; SUPERSENSITIVITY; D1-DOPAMINE; TERMINALS; STRIATUM;
Keywords:
DOPAMINE; DOPAMINE D-1 RECEPTOR; 6-HYDROXYDOPAMINE; SKF 38393; SEROTONIN; SEROTONIN RECEPTOR; M-CHLOROPHENYLPIPERAZINE; ONTOGENY; SUPERSENSITIZATION; ORAL ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L. Gong et al., "DOSE-RELATED EFFECTS OF A NEONATAL 6-OHDA LESION ON SKF 38393- AND M-CHLOROPHENYLPIPERAZINE-INDUCED ORAL ACTIVITY RESPONSES OF RATS", Developmental brain research, 76(2), 1993, pp. 233-238

Abstract

Neonatal 6-hydroxydopamine (6-OHDA) treatment of rats is associated with concurrent supersensitization of dopamine (DA) D-1 and serotonin 5-HT1C receptors, for agonist-induced oral activity. The present study was conducted to determine if graded reduction of striatal DA content and/or graded elevation of striatal 5-HT content by 6-OHDA would altersensitivity of either receptor type, and thereby influence oral activity responses to DA and 5-HT agonists. At 3 days after birth, groups of rats were pretreated with desipramine (20 mg/kg i.p.), 1 h before administration of a range of doses of 6-OHDA HBr (15, 30, 60, 100, 150 and 200 mu g, i.c.v., salt form; half in each lateral ventricle) or thevehicle, saline (0.85%)-ascorbic acid (0.1%). Between 2 and 4 months,a series of challenge doses of SKF 38393 HCl (0.30 to 3.0 mg/kg i.p.)and m-chlorophenylpiperazine 2HCl (0.30 to 6.0 mg/kg i.p; m-CPP 2HCl)were administered to each group of rats and oral activity was observed. Oral activity was determined for 1 min every 10 min during a 60-minperiod, starting 10 min after injection of agonist or vehicle. SKF 38393 dose-response curves demonstrated enhanced oral activity responsesin rats lesioned neonatally with 150 or 200 mu g of 6-OHDA. m-CPP dose-response curves demonstrated enhanced oral activity responses in these 2 groups of rats, as well as those lesioned neonatally with 100 mu g of 6-OHDA. Striatal DA content was reduced by > 97% in these 3 groups of rats. Striatal 5-HT content was elevated by > 80% in rats treatedneonatally with 150- or 200-mu g doses of 6-OHDA, and by 50% in rats treated neonatally with the 100-mu g dose of 6-OHDA. Lower doses of 6-OHDA produced less of an effect on striatal DA and 5-HT content. Regression analysis determined that both SKF 38393- and m-CPP-induced oral activities were most closely correlated with the magnitude of change in striatal content of DA. These findings demonstrate that 5-HT agonistresponses can be enhanced when DA agonist responses are not enhanced. Also, in neonatal 6-OHDA-lesioned rats the extent of DA depletion vs.the extent of 5-HT elevation seems to be a critical factor in the enhanced behavioral effects of DA and 5-HT agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:33:44