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Titolo:
PROTEIN DESIGNS FOR THE SPECIFIC RECOGNITION OF DNA
Autore:
KLUG A;
Indirizzi:
MRC,MOLEC BIOL LAB,HILLS RD CAMBRIDGE CB2 2QH ENGLAND
Titolo Testata:
Gene
fascicolo: 1-2, volume: 135, anno: 1993,
pagine: 83 - 92
SICI:
0378-1119(1993)135:1-2<83:PDFTSR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR-IIIA; ZINC-BINDING DOMAINS; CRYSTAL-STRUCTURE; GLUCOCORTICOID RECEPTOR; THYROID-HORMONE; COMPLEX; RESOLUTION; FINGERS; MOTIF; SWI5;
Keywords:
HELIX-TURN-HELIX; HOMOEODOMAIN; LEUCINE ZIPPER; ZINC FINGERS; HORMONE RECEPTORS; MODULAR DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Klug, "PROTEIN DESIGNS FOR THE SPECIFIC RECOGNITION OF DNA", Gene, 135(1-2), 1993, pp. 83-92

Abstract

The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic nucleotide sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains which bind specifically to the DNA sites (or response elements). Some generalprinciples in the design of these DNA-binding domains are described, followed by examples of the different structural classes discovered sofar and how they recognise their binding sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:12:48