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Titolo:
NA-ATPASE ACTIVITY IN CNS AND NORADRENERGIC NEUROTRANSMISSION - TIME-COURSE OF DIFFERENTIAL DESIPRAMINE (DMI) EFFECTS(, K+)
Autore:
VIOLA MS; ARNAIZ GRD; ENERO MA;
Indirizzi:
UNIV BUENOS AIRES,FAC MED,INST BIOL CELULAR,PARAGUAY 2155 RA-1121 BUENOS AIRES ARGENTINA UNIV BUENOS AIRES,FAC MED,INST BIOL CELULAR,PARAGUAY 2155 RA-1121 BUENOS AIRES ARGENTINA UNIV BUENOS AIRES,FAC FARM & BIOQUIM,CATEDRA FARMACOL BUENOS AIRES ARGENTINA CONSEJO NACL INVEST CIENT & TECN,INST INVEST FARMACOL RA-1113 BUENOS AIRES ARGENTINA
Titolo Testata:
Neurochemistry international
fascicolo: 1, volume: 24, anno: 1994,
pagine: 91 - 97
SICI:
0197-0186(1994)24:1<91:NAICAN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORADRENALINE UPTAKE SITES; SPONTANEOUS FIRING RATE; CENTRAL-NERVOUS-SYSTEM; BRAIN (NA+,K+)-ATPASE; PLASMA-MEMBRANE; SKELETAL-MUSCLE; OUABAIN BINDING; CEREBRAL-CORTEX; INVIVO; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Viola et al., "NA-ATPASE ACTIVITY IN CNS AND NORADRENERGIC NEUROTRANSMISSION - TIME-COURSE OF DIFFERENTIAL DESIPRAMINE (DMI) EFFECTS(, K+)", Neurochemistry international, 24(1), 1994, pp. 91-97

Abstract

ATPase activities in CNS membranes were studied after administration of desipramine (DMI). a noradrenaline (NA) uptake inhibitor. In a previous paper we reported that Na+, K+-ATPase activity significantly increased 3 h after DMI administration (10 mg/kg) in hypothalamus and mesencephalus but not in cerebral cortex and pons-medulla oblongata membranes (Viola et al., Cell. molec. Neurobiol. 1989, 9, 263-271). Here it was observed that Na+, K+-ATPase increase induced by acute DMI disappeared at 24 h in hypothalamus but remained during 21 days in mesencephalus. Na+, K+-ATPase increase by acute DMI was inhibited when endogenous NA was depleted by the noradrenergic neurotoxin DSP-4 or the NA synthesis inhibitor alpha-methyl-p-tyrosine. On the whole, Mg2+-ATPase activity was not modified by treatment. 5'-nucleotidase, another membrane-bound enzyme, was unchanged by acute DMI. The addition of DMI in vitro (50 ng/mg tissue) during Na+, K+-ATPase assay failed to affect ATPase activities. Acute DMI effects on Na+, K+-ATPase are thus attributable to noradrenergic neurotransmission rather than to non-specific drug-CNS membrane interaction. Furthermore, DMI produces differential effects on membrane Na+, K+-ATPase, depending on treatment conditions and CNS area studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:18:59