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Titolo:
MULTIPLE CHEMICAL-SENSITIVITY SYNDROME AND PORPHYRIA - A NOTE OF CAUTION AND CONCERN
Autore:
HAHN M; BONKOVSKY HL;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,CTR STUDY DISORDERS IRON & PORPHYRIN METAB,DIV DIGEST DIS & NUTR WORCESTER MA 01655 UNIV MASSACHUSETTS,MED CTR,CTR STUDY DISORDERS IRON & PORPHYRIN METAB,DIV DIGEST DIS & NUTR WORCESTER MA 01655 UNIV MASSACHUSETTS,MED CTR,DEPT MED WORCESTER MA 00000 UNIV MASSACHUSETTS,MED CTR,DEPT BIOCHEM & MOL BIOL WORCESTER MA 01605
Titolo Testata:
Archives of internal medicine
fascicolo: 3, volume: 157, anno: 1997,
pagine: 281 - 285
SICI:
0003-9926(1997)157:3<281:MCSAP->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; UROPORPHYRINOGEN DECARBOXYLASE; EXPOSURE; OXIDASE; MODEL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Hahn e H.L. Bonkovsky, "MULTIPLE CHEMICAL-SENSITIVITY SYNDROME AND PORPHYRIA - A NOTE OF CAUTION AND CONCERN", Archives of internal medicine, 157(3), 1997, pp. 281-285

Abstract

Growing numbers of patients suffering from many symptoms believe thatthey have a condition called multiple chemical sensitivity syndrome (MCSS). It has been suggested that this syndrome can be triggered by exposure to any of a large and usually incompletely defined number of natural and synthetic chemical substances. Major medical organizations, including the National Reseach Council and the American Medical Association, have not recognized MCSS as a clinical syndrome because of a lack of valid, well-controlled studies defining it and establishing pathogenesis or origin. Lately, some have proposed that many patients withMCSS suffer from hereditary coproporphyria. However, this purported association is based chiefly on results from a single reference laboratory of a fundamentally flawed assay for erythrocyte coproporphyrinogenoxidase. Although patients with MCS may, at times, have modest increases in urinary coproporphyrin excretion, this is a common finding found in many asymptomatic subjects or patients with diverse other conditions (eg, diabetes mellitus, heavy alcohol use, liver disease, and manykinds of anemia). Such secondary coproporphyrinuria does not indicatethe existence of coproporphyria. To our knowledge, there is no scientifically valid evidence to support an association between MCSS and coproporphyria, nor is there any unifying hypothesis for rationally linking these 2 disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:23:17