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Titolo:
DISSOCIATE ARACHIDONIC-ACID RELEASE FROM EICOSANOID SYNTHESIS IN RAT PERITONEAL-MACROPHAGES IS POSSIBLE USING CONCOMITANTLY EICOSAPENTANOICACID AS A PHOSPHOLIPID ANALOG
Autore:
BOURASS J; BOUCROT P; LETOURNEUX Y; GANDEMER G; PETIT JY;
Indirizzi:
INRA,LAB ETUD INTERACT MOL ALIMENTAIRES,BP 1627 F-44316 NANTES 03 FRANCE INRA,LAB ETUD INTERACT MOL ALIMENTAIRES F-44316 NANTES 03 FRANCE LAB SYNTH & ETUD SUBST NAT ACT BIOL F-17042 LA ROCHELLE 1 FRANCE FAC PHARM,LAB PHARMACOL & PHARMACOCINET F-44035 NANTES FRANCE
Titolo Testata:
Pharmacological research
fascicolo: 6, volume: 33, anno: 1996,
pagine: 343 - 347
SICI:
1043-6618(1996)33:6<343:DARFES>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACIDS; ALKYL-LYSOPHOSPHOLIPIDS; SELECTIVE DESTRUCTION; A(2) INHIBITION; LEUKEMIC-CELLS; PROSTAGLANDINS; METABOLISM; LIPIDS; ETHER; N-3;
Keywords:
MACROPHAGE; PHOSPHOLIPASE A-(2); ARACHIDONIC ACID; EICOSANOID; PHOSPHOLIPID ANALOG; EICOSAPENTANOIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Bourass et al., "DISSOCIATE ARACHIDONIC-ACID RELEASE FROM EICOSANOID SYNTHESIS IN RAT PERITONEAL-MACROPHAGES IS POSSIBLE USING CONCOMITANTLY EICOSAPENTANOICACID AS A PHOSPHOLIPID ANALOG", Pharmacological research, 33(6), 1996, pp. 343-347

Abstract

Activated macrophages exposed to the association of eicosapentanoic acid 20:5 n-3 and a synthetic non hydrolysable phospholipid analogue maintained a discrete synthesis of active eicosanoids. 20:4 n-6 splited from the internalized 20:4-GPC was accumulated in cells and extracellular fluids. This combination thus represents a novel approach to reduce the 20:4 n-6 cascade. (C) 1996 The Italian Pharmacological Society

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:53:15