Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE ELECTRICAL-STIMULATION INCREASES EXTRAMYOCARDIAL COLLATERAL BLOOD-FLOW AFTER A CARDIOMYOPLASTY
Autore:
MANNION JD; MAGNO MG; BUCKMAN PD; DIMEO F; GREENE R; BOWERS M; MCHUGH M; MENDUKE H;
Indirizzi:
THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV CARDIOTHORAC SURG,SUITE 607 COLL,1025 WALNUT ST PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV PATHOL PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV PHARMACOL PHILADELPHIA PA 19107
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 6, volume: 56, anno: 1993,
pagine: 1351 - 1358
SICI:
0003-4975(1993)56:6<1351:AEIECB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC CARDIOMYOPLASTY; SKELETAL-MUSCLE; CORONARY; MYOCARDIUM; CIRCULATION; OCCLUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Mannion et al., "ACUTE ELECTRICAL-STIMULATION INCREASES EXTRAMYOCARDIAL COLLATERAL BLOOD-FLOW AFTER A CARDIOMYOPLASTY", The Annals of thoracic surgery, 56(6), 1993, pp. 1351-1358

Abstract

We hypothesized that acute electrical stimulation of a latissimus dorsi cardiomyoplasty would augment the collateral blood now delivered bythe skeletal muscle to the heart. This hypothesis was tested in an animal model (13 goats) of coronary artery disease. Six weeks after a cardiomyoplasty was performed, myocardial collateral blood how derived from the latissimus dorsi muscle was measured with colored microsphereswhen the muscle was at rest and during electrical stimulation of the thoracodorsal nerve at 1.25 Hz. The area at risk for ischemia averaged13.37 +/- 2.08 g (mean +/- standard error), or 18.4% of left ventricular mass (n = 13). At rest, significant skeletal muscle-derived collaterals developed in 9 animals, and formed predominantly to chronic ischemic myocardium (mean +/- standard error, 0.07 +/- 0.02 mL.g(-1).min(-1); n = 9), rather than infarct (0.03 +/- 0.02 mL.g(-1).min(-1); n = 5), or normal myocardium (0.0005 +/- 0.0001 mL.g(-1).min(-1); n = 9). Stimulation increased skeletal muscle-derived collateral blood flow to chronic ischemic areas to 0.38 +/- 0.09 mL.g(-1).min(-1) (n = 9) (p < 0.05). During stimulation, the collateral flow was greater in the epicardium (0.46 +/- 0.11 mL.g(-1).min(-1)) than in endocardium (0.14 +/- 0.09 mL.g(-1).min(-1)) (p < 0.05). This study demonstrates that electrical stimulation of a latissimus dorsi cardiomyoplasty increases extramyocardial collateral blood flow to chronic ischemic myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:22:52