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Titolo:
ACUTE EXERCISE AND SKELETAL-MUSCLE ANTIOXIDANT AND METABOLIC ENZYMES - EFFECTS OF FIBER-TYPE AND AGE
Autore:
LAWLER JM; POWERS SK; VISSER T; VANDIJK H; KORDUS MJ; JI LL;
Indirizzi:
TEXAS A&M UNIV,DEPT HLTH & KINESIOL,HUMAN PERFORMANCE LABS COLL STN TX 77843 UNIV FLORIDA,CTR EXERCISE SCI,DEPT EXERCISE & SPORT SCI GAINESVILLE FL 32611 UNIV FLORIDA,DEPT PHYSIOL GAINESVILLE FL 32611 UNIV ILLINOIS,DEPT KINESIOL URBANA IL 61801
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 265, anno: 1993,
parte:, 2
pagine: 180001344 - 180001350
SICI:
0002-9513(1993)265:6<180001344:AEASAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; GLUTATHIONE; INTENSITY; PHOSPHOFRUCTOKINASE; OXIDATION; RADICALS; CAPACITY;
Keywords:
CITRATE SYNTHASE; ENZYME INHIBITION; GLUTATHIONE PEROXIDASE; 3-HYDROXYACYL-COA DEHYDROGENASE; MALONDIALDEHYDE; PHOSPHOFRUCTOKINASE; RAT; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Lawler et al., "ACUTE EXERCISE AND SKELETAL-MUSCLE ANTIOXIDANT AND METABOLIC ENZYMES - EFFECTS OF FIBER-TYPE AND AGE", The American journal of physiology, 265(6), 1993, pp. 180001344-180001350

Abstract

Inhibition of metabolic enzyme activity has been associated with freeradical stress in locomotor muscle with prolonged or intense exercise. However, it is not known whether such alterations with acute exercise in skeletal muscle are influenced by muscle fiber type or age. Twenty 4-mo-old and twenty 24-mo-old female Fischer-344 rats were divided at random into young exercised (YE; n - 10), old exercised (OE; n = 10), young control (YC; n = 10), and old control (OC; n = 10) groups. Animals in both YE and OE groups ran on a treadmill (10% uphill grade) for 40 min at approximately 75% of each age-group's maximal O2 consumption. Immediately after the treadmill run, white gastrocnemius (WG), redgastrocnemius (RG), and soleus (SOL) muscles were removed and quick-frozen in liquid nitrogen. Malondialdehyde was significantly increased (P < 0.05) in RG of YE vs. YC rats. Glutathione peroxidase activity was significantly elevated (P < 0.05) in the WG of YE rats. Analysis of variance revealed a significant overall increase in superoxide dismutase activity with exercise. Activities of phosphofructokinase (PFK), citrate synthase, succinate dehydrogenase, and 3-hydroxyacyl-CoA dehydrogenase were unchanged (P > 0.05) with acute exercise in the SOL. However, PFK activity was decreased in the WG by 60% in OE but only 33% in YE, and in the RG by 41% in OE but only 21% in YE. We conclude that maximal glycolytic flux in the gastrocnemius may be adversely affected by acute exercise, and this effect was more pronounced in the 24-mo-oldgroup.

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Documento generato il 02/12/20 alle ore 15:09:41