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Titolo:
TONIC DESCENDING MODULATION OF SPINAL NEURONAL RESPONSES TO ACTIVATION OF RENAL RECEPTORS
Autore:
STANDISH A; VIZZARD MA; AMMONS WS;
Indirizzi:
THOMAS JEFFERSON UNIV,DEPT PHYSIOL PHILADELPHIA PA 19107
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 265, anno: 1993,
parte:, 2
pagine: 180001291 - 180001303
SICI:
0002-9513(1993)265:6<180001291:TDMOSN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENORENAL REFLEXES; URETERAL OCCLUSION; VISCERAL INPUT; STIMULATION; RAT; CHEMORECEPTORS; NERVES; CAT; MECHANORECEPTORS; KIDNEY;
Keywords:
RENAL AFFERENT NERVES; COLD BLOCK; RENAL REFLEXES; RENAL MECHANORECEPTORS; RENAL CHEMORECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Standish et al., "TONIC DESCENDING MODULATION OF SPINAL NEURONAL RESPONSES TO ACTIVATION OF RENAL RECEPTORS", The American journal of physiology, 265(6), 1993, pp. 180001291-180001303

Abstract

Experiments were conducted in anesthetized cats to determine if spinal neuronal responses to activation of renal receptors are tonically modulated by descending spinal pathways. Eighty-seven thoracolumbar spinal neurons with renal and somatic input were tested for responses to occlusion of the renal vein, renal artery, and ureter before, during, and after cooling the spinal cord rostral to the recording site. Cooling increased the number of neurons that responded as well as the magnitude of the responses to renal vein (RVO), renal artery (RAO), and ureteral occlusion (UO). RVO increased cell activity of 21 neurons from 12.5 +/- 2.7 to 31.7 +/- 6.0 spikes/s during cooling. UO increased cell activity of 24 neurons from 9.0 +/- 2.1 before cooling to 25.0 +/- 4.9spikes/s during cooling. Cold block increased the magnitude of both types of responses to RAO that were due to mechanical deformation of the renal artery and prolonged renal ischemia. These data show that the majority of spinal neuronal responses to renal receptor stimulation are modulated by tonic inhibitory influences. Thus these results providea mechanism by which the brain may control spinal circuitry that underlies reflexes of renal origin.

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Documento generato il 19/09/20 alle ore 07:48:30