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Titolo:
ENDOTHELIN-1 AND ENDOTHELIN-3 CAUSE ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION IN THE RAT MESENTERIC-ARTERY
Autore:
NAKASHIMA M; VANHOUTTE PM;
Indirizzi:
IRIS,6 PL PLEIADES F-2415 COURBEVOIE FRANCE BAYLOR COLL MED,CTR EXPTL THERAPEUT HOUSTON TX 77030
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 265, anno: 1993,
parte:, 2
pagine: 80002137 - 80002141
SICI:
0002-9513(1993)265:6<80002137:EAECEH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; PORCINE CORONARY-ARTERY; RABBIT CAROTID-ARTERY; RECEPTOR; POTENT; PROSTACYCLIN; MECHANISM; ARGININE; RELEASE;
Keywords:
ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR; ENDOTHELIUM-DERIVED RELAXING FACTOR; ENDOTHELIN(B) RECEPTOR; BQ-123; IRL-1620; WISTAR-KYOTO RATS; SPONTANEOUSLY HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakashima e P.M. Vanhoutte, "ENDOTHELIN-1 AND ENDOTHELIN-3 CAUSE ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION IN THE RAT MESENTERIC-ARTERY", The American journal of physiology, 265(6), 1993, pp. 80002137-80002141

Abstract

The present study was designed to determine whether endothelin (ET) induces endothelium-dependent hyperpolarization in the isolated rat mesenteric artery and, if so, to identify the receptor subtype involved. Main superior mesenteric arteries of Wistar-Kyoto and spontaneously hypertensive rats were used for the measurement of electrical responses of smooth muscle cells, using glass microelectrode. In tissues with endothelium of both strains, ET-1 (10(-8) M) caused an initial transienthyperpolarization followed by a sustained depolarization. In tissues without endothelium, only depolarization was observed. ET-3 (10(-8) M)produced transient hyperpolarizations only in preparations with endothelium. There was no significant difference in maximal amplitude of hyperpolarization between the two strains. BQ-123 (selective ET(A)-receptor antagonist) blocked the depolarization to ET-1 but did not inhibithyperpolarizing responses to either isopeptide. IRL-1620 (specific ET(B)-receptor agonist) produced transient membrane hyperpolarizations in tissues with endothelium. The hyperpolarizations induced by ET were not affected by N(G)-nitro-L-arginine. These data suggest that both ET-1 and ET-3 can cause endothelium-dependent hyperpolarization in the rat mesenteric artery and that the endothelial receptor involved may belong to ET(B) subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:23:18