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Titolo:
FACTORS AFFECTING THE RATE AND ENERGETICS OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION
Autore:
WILSON DF;
Indirizzi:
UNIV PENN,SCH MED,DEPT BIOCHEM & BIOPHYS PHILADELPHIA PA 19104
Titolo Testata:
Medicine and science in sports and exercise
fascicolo: 1, volume: 26, anno: 1994,
pagine: 37 - 43
SICI:
0195-9131(1994)26:1<37:FATRAE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR-ENERGY METABOLISM; ISOLATED CARDIAC MYOCYTES; CORONARY BLOOD-FLOW; OXYGEN DEPENDENCE; REDUCTION REACTIONS; HEART-MITOCHONDRIA; RESPIRATION; ATP; GRADIENTS; PHOSPHATE;
Keywords:
MITOCHONDRIA; TISSUE RESPIRATION; OXIDATIVE PHOSPHORYLATION; MUSCLE; RESPIRATION; OXYGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Wilson, "FACTORS AFFECTING THE RATE AND ENERGETICS OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION", Medicine and science in sports and exercise, 26(1), 1994, pp. 37-43

Abstract

Mitochondrial oxidative phosphorylation in vivo is dependent on the degree of reduction of the intramitochondrial reducing power ([NADH]/[NAD(+)], cytoplasmic energy state ([ATP]/[ADP][Pi]) and intracellular oxygen pressure. Each parameter is independently regulated, and increased reducing power by activating the mitochondrial dehydrogenases allows higher energy state at a given rate of ATP synthesis or a higher rate of ATP synthesis at a given energy state. The mitochondrial respiratory rate is determined by demand, i.e., the rate of ATP utilization bythe cell, while the cellular energy state at that demand level is determined by Supply i.e., activity of the dehydrogenases expressed as [NADH]/[NAD(+)] and of cytoplasmic oxygen pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:47:08