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Titolo:
STRUCTURE OF DSG1, THE BOVINE DESMOSOMAL CADHERIN GENE ENCODING THE PEMPHIGUS FOLIACEUS ANTIGEN - EVIDENCE OF POLYMORPHISM
Autore:
PUTTAGUNTA S; MATHUR M; COWIN P;
Indirizzi:
NYU MED CTR,RONALD O PERELMAN DEPT DERMATOL,550 1ST AVE NEW YORK NY 10016 NYU MED CTR,RONALD O PERELMAN DEPT DERMATOL,550 1ST AVE NEW YORK NY 10016 NYU MED CTR,KAPLAN CANC CTR NEW YORK NY 10016 NYU MED CTR,DEPT CELL BIOL NEW YORK NY 10016
Titolo Testata:
The Journal of biological chemistry
fascicolo: 3, volume: 269, anno: 1994,
pagine: 1949 - 1955
SICI:
0021-9258(1994)269:3<1949:SODTBD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; CYTOPLASMIC DOMAIN; N-CADHERIN; XENOPUS EMBRYOS; FAMILY; UVOMORULIN; PROTEIN; GLYCOPROTEIN; JUNCTIONS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
S. Puttagunta et al., "STRUCTURE OF DSG1, THE BOVINE DESMOSOMAL CADHERIN GENE ENCODING THE PEMPHIGUS FOLIACEUS ANTIGEN - EVIDENCE OF POLYMORPHISM", The Journal of biological chemistry, 269(3), 1994, pp. 1949-1955

Abstract

The cadherin superfamily of calcium-dependent cell-cell adhesion and recognition proteins can be categorized into a number of subsets on the basis of the distinct cytoplasmic sequences of their members. Currently these families include classical cadherins, desmogleins, desmocollins, protocadherins, and the products of the Drosophila genes FAT and Dachsous. Dsg1, the prototype of the desmoglein family, is a major component of epidermal desmosomes and the antigenic target of antibodies found in the sera of patients with the blistering disease, pemphigus foliaceus. In this study, we determined the organization of the bovine DSG1 gene. This gene consists of 15 exons distributed over >37.5 kilobases of genomic DNA. A comparison of DSG1 with genes encoding classical cadherins revealed a striking conservation of exon boundaries in regions encoding the ectodomain and to a more limited extent among those encoding the cytoplasmic domain. Polymorphism was found in a sequence of DSG1 encoding protein proximal to the external face of the plasma membrane. This region is topologically equivalent to a domain of classical cadherins that harbors epitopes recognized by adhesion-disrupting antibodies. We discuss these results with regard to the evolution of the cadherin superfamily and their implications for the definition of pemphigus epitopes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:54:05