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Titolo:
SUSCEPTIBILITY OF HUMAN-MOUSE T-CELL HYBRIDS TO HIV-PRODUCTIVE INFECTION
Autore:
RAMARLI D; CAMBIAGGI C; MORGHEN CD; TRIPPUTI P; ORTOLANI R; BOLZANELLI M; TRIDENTE G; ACCOLLA RS;
Indirizzi:
POLICLIN BORGOROMA,IST IMMUNOL & MALATTIE INFECTT,VIA DELLE MENEGONE I-37134 VERONA ITALY UNIV VERONA,IST IMMUNOL & MALATTIE INFETT I-37100 VERONA ITALY UNIV MILAN,DIPARTIMENTO FARMACOL I-20100 MILAN ITALY UNIV MILAN,IST SCI BIOMED,OSPED S GERARDO I-20052 MONZA ITALY
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 12, volume: 9, anno: 1993,
pagine: 1269 - 1275
SICI:
0889-2229(1993)9:12<1269:SOHTHT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN CHROMOSOME-12; PERIPHERAL-BLOOD; RODENT CELLS; RETROVIRUSES; EXPRESSION; AIDS; RECEPTOR; ENCODES; TYPE-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D. Ramarli et al., "SUSCEPTIBILITY OF HUMAN-MOUSE T-CELL HYBRIDS TO HIV-PRODUCTIVE INFECTION", AIDS research and human retroviruses, 9(12), 1993, pp. 1269-1275

Abstract

Interspecies human x mouse cell hybrids were used to investigate the genetic basis of human permissivity to HTLV-III(B) infection. T cell hybrids between the mouse BW 51.47 T lymphoma line and normal, PHA-IL-2activated, human peripheral mononuclear cells (PBMCs) were generated. These hybrids preferentially segregated human chromosomes, as assessed by phenotype and karyotype analysis. Viral integration occurred onlyin those hybrids expressing CD4+ at the cell surface. However, infectious progeny production was demonstrated only in two of the three CD4hybrids tested. By segregation analysis, we could correlate the absence of human chromosomes 1, 3, and 9 with the lack of infectious viral progeny.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:03:57