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Titolo:
MORPHOGENIC POTENTIALS OF D-2, D-3, AND D-4 DOPAMINE-RECEPTORS REVEALED IN TRANSFECTED NEURONAL CELL-LINES
Autore:
SWARZENSKI BC; TANG L; OH YJ; OMALLEY KL; TODD RD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 2, volume: 91, anno: 1994,
pagine: 649 - 653
SICI:
0027-8424(1994)91:2<649:MPODDA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; EXPRESSION; CLONING; GROWTH; GENE; NEUROTRANSMITTERS; SCHIZOPHRENIA; GLUTAMATE; SEROTONIN; ONTOGENY;
Keywords:
NEURONAL DEVELOPMENT; MESENCEPHALIC CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Swarzenski et al., "MORPHOGENIC POTENTIALS OF D-2, D-3, AND D-4 DOPAMINE-RECEPTORS REVEALED IN TRANSFECTED NEURONAL CELL-LINES", Proceedings of the National Academy of Sciences of the United Statesof America, 91(2), 1994, pp. 649-653

Abstract

Molecular cloning studies have defined a family of dopamine D-2-like receptors (D-2, D-3, and D-4), Which are the products of separate genes. Our previous work has shown that stimulation of dopamine D-2-like receptors in cultures of fetal cortical neurons increases the extensionand branching of neurites. To determine which D-2 like receptors possess morphogenic potentials, a clonal mesencephalic cell line (MN9D) was transfected with D-2, D-3, Or D-4 receptor subtypes and treated withquinpirole, an agonist of D-2-like receptors, and changes in morphological characteristics were quantitated. Stimulation of D-2 receptors increased the number and branching of neurites with little effect on neurite extension; stimulation of D-3 and D-4 receptors increased the branching and extension of neurites. Similar results were found for primary mesencephalic cultures stimulated with quinpirole. These results suggest that the known D-2-like receptors have specific developmental roles in regulating neuronal morphogenesis of dopaminergic pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:10:27