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Titolo:
THE RELATION OF DOCUMENTED CORONARY-ARTERY DISEASE TO LEVELS OF TOTALCHOLESTEROL AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL
Autore:
FREEDMAN DS; CROFT JB; ANDERSON AJ; BYERS T; JACOBSEN SJ; GRUCHOW HW; WALKER JA; BARBORIAK JJ;
Indirizzi:
CTR DIS CONTROL,CTR CHRON DIS PREVENT & HLTH PROMOT,MAILSTOP K-26,4770 BUFORD HIGHWAY NE ATLANTA GA 30333
Titolo Testata:
Epidemiology
fascicolo: 1, volume: 5, anno: 1994,
pagine: 80 - 87
SICI:
1044-3983(1994)5:1<80:TRODCD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
CHOLESTEROL LEVELS; HDL LIPOPROTEINS; LDL LIPOPROTEINS; CORONARY ARTERY DISEASE; LIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Freedman et al., "THE RELATION OF DOCUMENTED CORONARY-ARTERY DISEASE TO LEVELS OF TOTALCHOLESTEROL AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL", Epidemiology, 5(1), 1994, pp. 80-87

Abstract

Recommendations for identifying persons at high risk for coronary heart disease are based primarily on levels of total and low-density lipoprotein cholesterol. We examined whether, given knowledge of these levels, information on the high-density lipoprotein cholesterol level would improve the prediction of arteriographically documented coronary artery disease among 591 men. We found that even at levels of total and low density lipoprotein cholesterol considered desirable, high-densitylipoprotein cholesterol was inversely related to disease severity. For example, among the 112 men with a total cholesterol level <180 mg per dl, the mean occlusion score (representing the overall severity of disease) was 107 among men with a high-density lipoprotein cholesterol level less than or equal to 30 mg per dl us a mean score of 52 among men with levels greater than or equal to 45 mg per dl. Furthermore, menwith low levels of both low-density lipoprotein cholesterol (<110 mg per dl) and high-density lipoprotein cholesterol (less than or equal to 30 mg per dl) had as much occlusive disease as did men with high levels of both lipoprotein fractions. Given information on the ratio of high-density lipoprotein cholesterol to total cholesterol, the actual levels of the lipoprotein fractions did nor improve disease prediction. Our results emphasize the importance of considering high-density lipoprotein cholesterol when assessing coronary heart disease risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:38:53