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Titolo:
CARDIOVASCULAR EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR IN RATS
Autore:
BOUSSAIRI EH; SASSARD J;
Indirizzi:
FAC PHARM LYON,DEPT PHYSIOL & CLIN PHARMACOL,CNRS,URA 1483,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE FAC PHARM LYON,DEPT PHYSIOL & CLIN PHARMACOL,CNRS,URA 1483 F-69373 LYON 08 FRANCE
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 1, volume: 23, anno: 1994,
pagine: 99 - 102
SICI:
0160-2446(1994)23:1<99:CEOBFG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY ENDOTHELIAL-CELLS; PLASMINOGEN-ACTIVATOR PRODUCTION; SPONTANEOUSLY HYPERTENSIVE RATS; DNA-SYNTHESIS; PURIFICATION; MIGRATION; HEPARIN; BINDING;
Keywords:
RAT; BLOOD PRESSURE; NITRIC OXIDE; PROSTANOIDS; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
E.H. Boussairi e J. Sassard, "CARDIOVASCULAR EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR IN RATS", Journal of cardiovascular pharmacology, 23(1), 1994, pp. 99-102

Abstract

We determined the effects of human basic fibroblast growth factor (bFGF) on blood pressure (BP) and heart rate (HR) in pentobarbital-anesthetized rats and examined the possible involvement of nitric oxide (NO)and prostanoids in these effects. Intravenous (i.v.) injections of bFGF (1, 7.5, and 15 mu g/kg) induced dose-dependent short-lasting decreases in BP followed by a striking increase in BP and HR variability. The BP and HR increases in variability were closely related (r = 0.95; n = 20; p < 0.001). Pretreatment with a single intravenous (i.v.) doseof N omega-nitro-L-arginine methyl ester (L-NAME, 20 mg/kg) almost suppressed (-90%) the cardiovascular effects of bFGF, an effect that wasrestored by a single dose of L-arginine (100 mg/kg i.v.). similar suppression was observed with use of indomethacin (10 mg/kg i.v.). Indomethacin given 50-60 min after bFGF abolished the increased variability of BP and HR. We conclude that the BP decrease and the increase in BP and HR variability induced by bFGF involve release of both NO and vasoactive prostanoids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:48:52