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Titolo:
THE EFFECTS OF COMBINED INTRAVENOUS AND INHALED STEROIDS (BECLOMETHASONE DIPROPIONATE) FOR THE EMERGENCY TREATMENT OF ACUTE ASTHMA
Autore:
GUTTMAN A; AFILALO M; COLACONE A; KREISMAN H; DANKOFF J; TSELIOS C; STERN E; WOLKOVE N;
Indirizzi:
MCGILL UNIV,SIR MORTIMER B DAVIS JEWISH HOSP,EMERGENCY DEPT,ROOM C-015 MONTREAL PQ H3T 1E2 CANADA MCGILL UNIV,SIR MORTIMER B DAVIS JEWISH HOSP,DEPT INTERNAL MED,DIV PULM MONTREAL PQ H3T 1E2 CANADA
Titolo Testata:
Academic emergency medicine
fascicolo: 2, volume: 4, anno: 1997,
pagine: 100 - 106
SICI:
1069-6563(1997)4:2<100:TEOCIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED TRIAL; ACUTE EXACERBATIONS; ORAL PREDNISONE; THERAPY; CORTICOSTEROIDS; IPRATROPIUM; EFFICACY; METHYLPREDNISOLONE; CHILDREN; AEROSOL;
Keywords:
ACUTE ASTHMA; EMERGENCY TREATMENT; INHALED STEROIDS; CORTICOSTEROIDS; RESPIRATORY DISTRESS; BRONCHOSPASM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Guttman et al., "THE EFFECTS OF COMBINED INTRAVENOUS AND INHALED STEROIDS (BECLOMETHASONE DIPROPIONATE) FOR THE EMERGENCY TREATMENT OF ACUTE ASTHMA", Academic emergency medicine, 4(2), 1997, pp. 100-106

Abstract

Objective: To compare the efficacy of high-dose inhaled steroids in conjunction with IV steroids with that of IV steroids alone in the emergency treatment for acute asthma. Methods: A double-blind, placebo-controlled, randomized trial was conducted on 60 ED patients presenting with acute asthma. All patients received nebulized salbutamol, and IV methylprednisolone, 80 mg at baseline and 40 mg at 6 hours. In additionto the above therapy, the experimental group received beclomethasone dipropionate (BDP) 7 mg over 8 hours via a metered-dose inhaler (MDI) attached to a holding chamber, while the central group received a placebo administered in the same fashion. Patients were treated on the protocol for 12 hours with the primary outcome measure being the change in % predicted FEV(1). Results: Of 60 patients, 30 were randomized to BDP (age: 42+/-16 years; FEV(1): 0.97+/-0.42 L) and 30 were randomized to placebo (age: 37+/-18 years; FEV,: 0.98+/-0.35 L), Spirometry and dyspnea measured by the Borg Scale improved significantly in both groups compared with baseline (p <0.001). Changes in spirometry measures, dyspnea, and vital signs did not differ between treatment groups over the 12 hours of study (p >0.05). Conclusion: Inhaled BDP added to the standard regimen of IV methylprednisolone, and beta-agonist did not further improve flow rates or dyspnea scores measured for up to 12 hours after presentation to the ED.

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Documento generato il 22/01/20 alle ore 12:54:24