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Titolo:
ANTIBODY-RESPONSE TO A SYNTHETIC PEPTIDE DERIVED FROM THE HUMAN PAPILLOMAVIRUS TYPE 6 11 L2 PROTEIN IN RECURRENT RESPIRATORY PAPILLOMATOSIS- CORRELATION BETWEEN SOUTHERN BLOT HYBRIDIZATION, POLYMERASE CHAIN-REACTION, AND SEROLOGY/
Autore:
TACHEZY R; HAMSIKOVA E; VALVODA J; VANRANST M; BETKA J; BURK RD; VONKA V;
Indirizzi:
ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL,ULLMANN BLDG,ROOM 515,1300 MORRIS PK AVE BRONX NY 10461 CHARLES UNIV,INST HEMATOL & BLOOD TRANSFUS,DEPT EXPTL VIROL PRAGUE CZECH REPUBLIC CHARLES UNIV,FAC MED 1,DEPT OTORHINOLARYNGOL PRAGUE CZECH REPUBLIC ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 00000
Titolo Testata:
Journal of medical virology
fascicolo: 1, volume: 42, anno: 1994,
pagine: 52 - 59
SICI:
0146-6615(1994)42:1<52:ATASPD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE LARYNGEAL PAPILLOMATOSIS; SQUAMOUS-CELL CARCINOMAS; INSITU DNA HYBRIDIZATION; CONDYLOMATA-ACUMINATA; HUMAN-SERA; IDENTIFICATION; VIRUS; CLASSIFICATION; SEQUENCES; EPITOPES;
Keywords:
HPV; HUMAN PAPILLOMAVIRUS; LARYNX; PCR; SEROLOGY; RECURRENT RESPIRATORY PAPILLOMATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
R. Tachezy et al., "ANTIBODY-RESPONSE TO A SYNTHETIC PEPTIDE DERIVED FROM THE HUMAN PAPILLOMAVIRUS TYPE 6 11 L2 PROTEIN IN RECURRENT RESPIRATORY PAPILLOMATOSIS- CORRELATION BETWEEN SOUTHERN BLOT HYBRIDIZATION, POLYMERASE CHAIN-REACTION, AND SEROLOGY/", Journal of medical virology, 42(1), 1994, pp. 52-59

Abstract

Recurrent respiratory papillomatosis (RRP) is the most common benign tumour of the larynx, affecting both children and adults. We present aseries of 25 patients, including 10 cases of juvenile multiple, 8 cases of adult solitary, and 7 cases of adult multiple RRP. Biopsy tissuefrom each patient was screened by Southern blot hybridization and polymerase chain reaction for the presence of human papillomavirus (HPV) DNA. Sera from patients and age- and sex-matched controls were tested for the presence of HPV-specific antibodies using a synthetic peptide derived from the minor capsid protein (L2) of HPV 6/11. By Southern blot hybridization and/or polymerase chain reaction, biopsies from all patients were positive for HPV 6/11 DNA. There was no difference in antibody response between cases and controls. Female cases and controls had significantly higher antibody titers than male subjects. A correlation was observed between the HPV-specific antibody level and the number of surgery-necessitating recurrences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:48:55